Identification of a fish protein associated with a kinase activity and related to the Rous sarcoma virus transforming protein

Cells of all vertebrates thus far investigated contain a cellular src gene, which appears to be a highly conserved homolog of the Rous sarcoma virus oncogene src. Similar to the Rous sarcoma virus oncogene src, this endogenous cellular src gene codes for a M sub(r) 60,000 phosphoprotein (pp60 super(...

Full description

Saved in:
Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1982-06, Vol.42 (6), p.2429-2433
Main Authors: Barnekow, A, Schartl, M, Anders, F, Bauer, H
Format: Article
Language:English
Subjects:
Animals
Avian Sarcoma Viruses - genetics
Brain - enzymology
Cell Transformation, Viral
Chick Embryo
Crosses, Genetic
Fishes - genetics
Freshwater
Girardinus
Molecular Weight
Oncogene Protein pp60(v-src)
Protein Kinases - genetics
Protein Kinases - isolation & purification
Species Specificity
Viral Proteins - genetics
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cells of all vertebrates thus far investigated contain a cellular src gene, which appears to be a highly conserved homolog of the Rous sarcoma virus oncogene src. Similar to the Rous sarcoma virus oncogene src, this endogenous cellular src gene codes for a M sub(r) 60,000 phosphoprotein (pp60 super(c-src)) which is associated with a kinases activity. This kinase specifically phosphorylates tyrosine residues of proteins. All animals of the various strains of the fish investigated (including Xiphorus and Girardinus ) in this study showed kinase activity that was reactive upon immunoprecipitation with tumor-bearing rabbit serum, indicating that the pp60 super(c-src) protein is a normal constituent of the fish. Measurable quantitative differences were revealed between the various strains as well as in different tissues.
ISSN:0008-5472