Immunology of human gastric cancer: A preliminary report

The immunological spectrum in fifteen patients with gastric cancer is presented. Patients were divided in three groups. Those with nonadvanced cancer, those with advanced but resectable lesions and those with advanced but nonresectable tumors. Preoperatively, elevated levels of circulating immune co...

Full description

Saved in:
Bibliographic Details
Published in:Cancer 1982-05, Vol.49 (9), p.1810-1816
Main Authors: Blanca, Isaac, Grases, Pedro J., Matos V, Marcos, Contreras, Carmen Elena, Ochoa, Mariangel, Wright, Harlam, Bianco C, Nicolàs
Format: Article
Language:English
Subjects:
Adult
Aged
Antibody-Dependent Cell Cytotoxicity
Antigen-Antibody Complex - analysis
Cell Migration Inhibition
Female
Humans
Leukocyte Migration-Inhibitory Factors - analysis
Lymphocyte Activation
Lymphocyte Culture Test, Mixed
Male
Middle Aged
Prospective Studies
Stomach Neoplasms - immunology
Stomach Neoplasms - surgery
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites cdi_FETCH-LOGICAL-c4693-c0dafc205df7a729dade69171136c76e95adf7135a1534b11943e96f615bb6083
container_end_page 1816
container_issue 9
container_start_page 1810
container_title Cancer
container_volume 49
creator Blanca, Isaac
Grases, Pedro J.
Matos V, Marcos
Contreras, Carmen Elena
Ochoa, Mariangel
Wright, Harlam
Bianco C, Nicolàs
description The immunological spectrum in fifteen patients with gastric cancer is presented. Patients were divided in three groups. Those with nonadvanced cancer, those with advanced but resectable lesions and those with advanced but nonresectable tumors. Preoperatively, elevated levels of circulating immune complexes (CIC) associated with hyporesponsiveness to phytohemagglutinin (PHA) and in mixed lymphocyte culture (MLC) as well as a positive leukocyte inhibitory serum factor (LIF‐S) were found in nearly half of the patients. Inhibitory or enhancing autologous serum factors were detected. Postoperatively, immunologic parameters return to normal in patients with nonadvanced cancer, while in advanced cancer, antibody and cell‐mediated immune response remained altered, with some changes associated with chemotherapy. These findings are probably related with the presence or absence of tumor and offer a distinct approach in evaluating the immunologic response of a tumor‐bearing patient.
doi_str_mv 10.1002/1097-0142(19820501)49:9<1810::AID-CNCR2820490913>3.0.CO;2-2
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_74047906</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>74047906</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4693-c0dafc205df7a729dade69171136c76e95adf7135a1534b11943e96f615bb6083</originalsourceid><addsrcrecordid>eNqVkE1rGzEQhkVoSN00P6Gwp9Ac1p2RtNqVWwJmkzaGEENpIZDDIGu16Zb9cCUvxf--MnYDzaGQ0zA8o3dGD2MlwhQB-AcEnaeAkr9HXXDIAC-knulPWCDMZvPFVVrelV95RFKDRnEppjAtlx95yo_Y5On1KzYBgCLNpLh_zd6E8DO2Oc_ECTtRHEHyYsKKRdeN_dAOj9tkqJMfY2f65NGEjW9sYk1vnZ8l82TtXdt0TW_8NvFuPfjNW3Zcmza4s0M9Zd8_X38rb9Lb5ZdFOb9NrVRapBYqU9v4iarOTc51ZSqnNOaIQtlcOZ2ZSFBkBjMhV4haCqdVrTBbrRQU4pSd73PXfvg1urChrgnWta3p3TAGyiXIXIOKgw_7QeuHELyrae2bLh5MCLTzSjsztDNDf72S1KRp55UoeqV_vZIgoHJJnHhMf3c4Y1x1rnrKPoiMvN7z303rti9b_d_Nz4j4AzCFk9w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>74047906</pqid></control><display><type>article</type><title>Immunology of human gastric cancer: A preliminary report</title><source>EZB Electronic Journals Library</source><creator>Blanca, Isaac ; Grases, Pedro J. ; Matos V, Marcos ; Contreras, Carmen Elena ; Ochoa, Mariangel ; Wright, Harlam ; Bianco C, Nicolàs</creator><creatorcontrib>Blanca, Isaac ; Grases, Pedro J. ; Matos V, Marcos ; Contreras, Carmen Elena ; Ochoa, Mariangel ; Wright, Harlam ; Bianco C, Nicolàs</creatorcontrib><description>The immunological spectrum in fifteen patients with gastric cancer is presented. Patients were divided in three groups. Those with nonadvanced cancer, those with advanced but resectable lesions and those with advanced but nonresectable tumors. Preoperatively, elevated levels of circulating immune complexes (CIC) associated with hyporesponsiveness to phytohemagglutinin (PHA) and in mixed lymphocyte culture (MLC) as well as a positive leukocyte inhibitory serum factor (LIF‐S) were found in nearly half of the patients. Inhibitory or enhancing autologous serum factors were detected. Postoperatively, immunologic parameters return to normal in patients with nonadvanced cancer, while in advanced cancer, antibody and cell‐mediated immune response remained altered, with some changes associated with chemotherapy. These findings are probably related with the presence or absence of tumor and offer a distinct approach in evaluating the immunologic response of a tumor‐bearing patient.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/1097-0142(19820501)49:9&lt;1810::AID-CNCR2820490913&gt;3.0.CO;2-2</identifier><identifier>PMID: 6210428</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Aged ; Antibody-Dependent Cell Cytotoxicity ; Antigen-Antibody Complex - analysis ; Cell Migration Inhibition ; Female ; Humans ; Leukocyte Migration-Inhibitory Factors - analysis ; Lymphocyte Activation ; Lymphocyte Culture Test, Mixed ; Male ; Middle Aged ; Prospective Studies ; Stomach Neoplasms - immunology ; Stomach Neoplasms - surgery</subject><ispartof>Cancer, 1982-05, Vol.49 (9), p.1810-1816</ispartof><rights>Copyright © 1982 American Cancer Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4693-c0dafc205df7a729dade69171136c76e95adf7135a1534b11943e96f615bb6083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6210428$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Blanca, Isaac</creatorcontrib><creatorcontrib>Grases, Pedro J.</creatorcontrib><creatorcontrib>Matos V, Marcos</creatorcontrib><creatorcontrib>Contreras, Carmen Elena</creatorcontrib><creatorcontrib>Ochoa, Mariangel</creatorcontrib><creatorcontrib>Wright, Harlam</creatorcontrib><creatorcontrib>Bianco C, Nicolàs</creatorcontrib><title>Immunology of human gastric cancer: A preliminary report</title><title>Cancer</title><addtitle>Cancer</addtitle><description>The immunological spectrum in fifteen patients with gastric cancer is presented. Patients were divided in three groups. Those with nonadvanced cancer, those with advanced but resectable lesions and those with advanced but nonresectable tumors. Preoperatively, elevated levels of circulating immune complexes (CIC) associated with hyporesponsiveness to phytohemagglutinin (PHA) and in mixed lymphocyte culture (MLC) as well as a positive leukocyte inhibitory serum factor (LIF‐S) were found in nearly half of the patients. Inhibitory or enhancing autologous serum factors were detected. Postoperatively, immunologic parameters return to normal in patients with nonadvanced cancer, while in advanced cancer, antibody and cell‐mediated immune response remained altered, with some changes associated with chemotherapy. These findings are probably related with the presence or absence of tumor and offer a distinct approach in evaluating the immunologic response of a tumor‐bearing patient.</description><subject>Adult</subject><subject>Aged</subject><subject>Antibody-Dependent Cell Cytotoxicity</subject><subject>Antigen-Antibody Complex - analysis</subject><subject>Cell Migration Inhibition</subject><subject>Female</subject><subject>Humans</subject><subject>Leukocyte Migration-Inhibitory Factors - analysis</subject><subject>Lymphocyte Activation</subject><subject>Lymphocyte Culture Test, Mixed</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><subject>Stomach Neoplasms - immunology</subject><subject>Stomach Neoplasms - surgery</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><recordid>eNqVkE1rGzEQhkVoSN00P6Gwp9Ac1p2RtNqVWwJmkzaGEENpIZDDIGu16Zb9cCUvxf--MnYDzaGQ0zA8o3dGD2MlwhQB-AcEnaeAkr9HXXDIAC-knulPWCDMZvPFVVrelV95RFKDRnEppjAtlx95yo_Y5On1KzYBgCLNpLh_zd6E8DO2Oc_ECTtRHEHyYsKKRdeN_dAOj9tkqJMfY2f65NGEjW9sYk1vnZ8l82TtXdt0TW_8NvFuPfjNW3Zcmza4s0M9Zd8_X38rb9Lb5ZdFOb9NrVRapBYqU9v4iarOTc51ZSqnNOaIQtlcOZ2ZSFBkBjMhV4haCqdVrTBbrRQU4pSd73PXfvg1urChrgnWta3p3TAGyiXIXIOKgw_7QeuHELyrae2bLh5MCLTzSjsztDNDf72S1KRp55UoeqV_vZIgoHJJnHhMf3c4Y1x1rnrKPoiMvN7z303rti9b_d_Nz4j4AzCFk9w</recordid><startdate>19820501</startdate><enddate>19820501</enddate><creator>Blanca, Isaac</creator><creator>Grases, Pedro J.</creator><creator>Matos V, Marcos</creator><creator>Contreras, Carmen Elena</creator><creator>Ochoa, Mariangel</creator><creator>Wright, Harlam</creator><creator>Bianco C, Nicolàs</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19820501</creationdate><title>Immunology of human gastric cancer: A preliminary report</title><author>Blanca, Isaac ; Grases, Pedro J. ; Matos V, Marcos ; Contreras, Carmen Elena ; Ochoa, Mariangel ; Wright, Harlam ; Bianco C, Nicolàs</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4693-c0dafc205df7a729dade69171136c76e95adf7135a1534b11943e96f615bb6083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antibody-Dependent Cell Cytotoxicity</topic><topic>Antigen-Antibody Complex - analysis</topic><topic>Cell Migration Inhibition</topic><topic>Female</topic><topic>Humans</topic><topic>Leukocyte Migration-Inhibitory Factors - analysis</topic><topic>Lymphocyte Activation</topic><topic>Lymphocyte Culture Test, Mixed</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prospective Studies</topic><topic>Stomach Neoplasms - immunology</topic><topic>Stomach Neoplasms - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Blanca, Isaac</creatorcontrib><creatorcontrib>Grases, Pedro J.</creatorcontrib><creatorcontrib>Matos V, Marcos</creatorcontrib><creatorcontrib>Contreras, Carmen Elena</creatorcontrib><creatorcontrib>Ochoa, Mariangel</creatorcontrib><creatorcontrib>Wright, Harlam</creatorcontrib><creatorcontrib>Bianco C, Nicolàs</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Blanca, Isaac</au><au>Grases, Pedro J.</au><au>Matos V, Marcos</au><au>Contreras, Carmen Elena</au><au>Ochoa, Mariangel</au><au>Wright, Harlam</au><au>Bianco C, Nicolàs</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunology of human gastric cancer: A preliminary report</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>1982-05-01</date><risdate>1982</risdate><volume>49</volume><issue>9</issue><spage>1810</spage><epage>1816</epage><pages>1810-1816</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><abstract>The immunological spectrum in fifteen patients with gastric cancer is presented. Patients were divided in three groups. Those with nonadvanced cancer, those with advanced but resectable lesions and those with advanced but nonresectable tumors. Preoperatively, elevated levels of circulating immune complexes (CIC) associated with hyporesponsiveness to phytohemagglutinin (PHA) and in mixed lymphocyte culture (MLC) as well as a positive leukocyte inhibitory serum factor (LIF‐S) were found in nearly half of the patients. Inhibitory or enhancing autologous serum factors were detected. Postoperatively, immunologic parameters return to normal in patients with nonadvanced cancer, while in advanced cancer, antibody and cell‐mediated immune response remained altered, with some changes associated with chemotherapy. These findings are probably related with the presence or absence of tumor and offer a distinct approach in evaluating the immunologic response of a tumor‐bearing patient.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>6210428</pmid><doi>10.1002/1097-0142(19820501)49:9&lt;1810::AID-CNCR2820490913&gt;3.0.CO;2-2</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0008-543X
ispartof Cancer, 1982-05, Vol.49 (9), p.1810-1816
issn 0008-543X
1097-0142
language eng
recordid cdi_proquest_miscellaneous_74047906
source EZB Electronic Journals Library
subjects Adult
Aged
Antibody-Dependent Cell Cytotoxicity
Antigen-Antibody Complex - analysis
Cell Migration Inhibition
Female
Humans
Leukocyte Migration-Inhibitory Factors - analysis
Lymphocyte Activation
Lymphocyte Culture Test, Mixed
Male
Middle Aged
Prospective Studies
Stomach Neoplasms - immunology
Stomach Neoplasms - surgery
title Immunology of human gastric cancer: A preliminary report
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T20%3A51%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Immunology%20of%20human%20gastric%20cancer:%20A%20preliminary%20report&rft.jtitle=Cancer&rft.au=Blanca,%20Isaac&rft.date=1982-05-01&rft.volume=49&rft.issue=9&rft.spage=1810&rft.epage=1816&rft.pages=1810-1816&rft.issn=0008-543X&rft.eissn=1097-0142&rft_id=info:doi/10.1002/1097-0142(19820501)49:9%3C1810::AID-CNCR2820490913%3E3.0.CO;2-2&rft_dat=%3Cproquest_cross%3E74047906%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c4693-c0dafc205df7a729dade69171136c76e95adf7135a1534b11943e96f615bb6083%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=74047906&rft_id=info:pmid/6210428&rfr_iscdi=true