Possible use of histone acetylation in mixed leukocyte cultures to assess histocompatibility

MIXED leukocyte cultures (MLC) have been extensively used to assess histocompatibility in transplantation 1–5 . The MLC test 6,7 is an in-vitro model for determining the early recognition phase of the homograft rejection, and a correlation between the blast transformation in the MLC and the outcome...

Full description

Saved in:
Bibliographic Details
Published in:Nature (London) 1978-06, Vol.273 (5662), p.467-469
Main Authors: MUKHERJEE, ANIL B, FABRICANT, JILL D
Format: Article
Language:English
Subjects:
Female
Histocompatibility Testing - methods
Histones - metabolism
HLA Antigens
Humanities and Social Sciences
Humans
Kidney - immunology
Kidney Transplantation
letter
Lymphocyte Activation
Lymphocyte Culture Test, Mixed
multidisciplinary
Pregnancy
Science
Science (multidisciplinary)
Time Factors
Twins, Dizygotic
Twins, Monozygotic
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:MIXED leukocyte cultures (MLC) have been extensively used to assess histocompatibility in transplantation 1–5 . The MLC test 6,7 is an in-vitro model for determining the early recognition phase of the homograft rejection, and a correlation between the blast transformation in the MLC and the outcome of cadaver kidney transplantation has been suggested 1–5,8 . However, the MLC test is limited in its use in cadaver kidney transplantation because of the extended period required for its completion. Therefore, a more rapid technique other than blast transformation in MLC is required to assess the potential success of kidney transplantation when cadaver donors must be used. We report here that acetylation of histones in MLC may be a time-saving technique to determine histocompatibility in cadaver kidney transplantation.
ISSN:0028-0836
1476-4687
DOI:10.1038/273467a0