Efficacy of antibiotics in bacteriobilia

Fifty-five per cent of t-tube samples show bacterial growth. Sterile biliary tracts remain sterile for three to five days after surgery, as measured by t-tube samples. Without antibiotics, no bacterial reduction occurred when more than 100,000 organisms were present in the bile. Administration of an...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 1982, Vol.9 (suppl-A), p.131-137
Main Authors: Wacha, H., Helm, E. B.
Format: Article
Language:English
Subjects:
Aged
Anti-Bacterial Agents - therapeutic use
Bacteria - drug effects
Bacterial Infections - drug therapy
Bile - microbiology
Biliary Tract Diseases - surgery
Female
Humans
Male
Middle Aged
Wound Infection - drug therapy
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Summary:Fifty-five per cent of t-tube samples show bacterial growth. Sterile biliary tracts remain sterile for three to five days after surgery, as measured by t-tube samples. Without antibiotics, no bacterial reduction occurred when more than 100,000 organisms were present in the bile. Administration of antibiotics did not result in reduction of bile bacterial counts when tetracycline or aminoglycosides were given. Mezlocillin caused marked reduction and even elimination of bacteria from bile. However, antibiotic therapy for the treatment of bacterial infection of the bile is reasonable only after decompression of obstructive jaundice since levels of antibiotic in bile are achieved only in the absence of obstruction.
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/9.suppl_A.131