Internalisation of gonadotrophin-receptor complex in ovarian luteal cells

IT is generally accepted that peptide and protein hormones bind to plasma membrane receptors on target cells 1 and elicit their acute responses without entering the cell. The refractory or desensitised state induced by various hormones in target tissues has been shown to be mediated at least in part...

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Bibliographic Details
Published in:Nature (London) 1978-08, Vol.274 (5671), p.598-600
Main Authors: CONN, P. MICHAEL, CONTI, MARCO, HARWOOD, JAMES P, DUFAU, MARIA L, CATT, KEVIN J
Format: Article
Language:English
Subjects:
Animals
Biological Transport, Active
Cell Membrane - metabolism
Chorionic Gonadotropin - metabolism
Corpus Luteum - metabolism
Female
Humanities and Social Sciences
letter
Luteal Cells - metabolism
multidisciplinary
Rats
Receptors, Cell Surface - metabolism
Science
Science (multidisciplinary)
Solubility
Time Factors
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Summary:IT is generally accepted that peptide and protein hormones bind to plasma membrane receptors on target cells 1 and elicit their acute responses without entering the cell. The refractory or desensitised state induced by various hormones in target tissues has been shown to be mediated at least in part by loss of specific receptor sites from the plasma membrane 2–7 . Evidence that certain protein hormones can enter target cells 8–10 led us to the present investigation which provides evidence that gonadotrophin-induced receptor loss may occur by a process of internalisation of the hormone–receptor complex following the initial interaction of gonadotrophin with the cell surface.
ISSN:0028-0836
1476-4687
DOI:10.1038/274598a0