Chronic Leukemia With a Hybrid Surface Phenotype (T Lymphocytic/Myelomonocytic): Leukemic Cells Displaying Natural Killer Activity and Antibody-Dependent Cellular Cytotoxicity

A patient with chronic leukemia exhibited uncommon clinical features, such as hypergammaglobulinemia and activation of intravascular coagulation after low-dose irradiation of the enlarged spleen. By light and electron microscopy, the leukemic cells resembled large granular lymphocytes. The following...

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Bibliographic Details
Published in:Blood 1982-06, Vol.59 (6), p.1157-1162
Main Authors: Schlimok, Günter, Thiel, Eckhard, Rieber, Ernst Peter, Huhn, Dieter, Feucht, Helmut, Lohmeyer, Jürgen, Riethmüller, Gert
Format: Article
Language:English
Subjects:
Aged
Antibody-Dependent Cell Cytotoxicity
Antigens, Surface - analysis
B-Lymphocytes - immunology
Humans
Killer Cells, Natural - immunology
Leukemia, Lymphoid - immunology
Leukemia, Lymphoid - ultrastructure
Lymphocytes - classification
Male
Receptors, Antigen, B-Cell - analysis
Rosette Formation
T-Lymphocytes - immunology
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Summary:A patient with chronic leukemia exhibited uncommon clinical features, such as hypergammaglobulinemia and activation of intravascular coagulation after low-dose irradiation of the enlarged spleen. By light and electron microscopy, the leukemic cells resembled large granular lymphocytes. The following markers were simultaneously expressed on their surface: receptors for sheep erythrocytes and the Fc part of IgG; common T-cell antigens as revealed by a heteroantiserum (HuTLA) and monoclonal antibodies (OKT3. T411); antigens shared by cytotoxic/suppressor T cells (OKT8, T811) as well as myelomonocytic antigens defined by the OKM1 and M522 monoclonal antibodies. The leukemic cells showed both spontaneous (NK) and antibody-dependent (ADCC) cytotoxicity, but they did not suppress B-cell differentiation in vitro.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V59.6.1157.1157