GLOBOMYCIN, A NEW PEPTIDE ANTIBIOTIC WITH SPHEROPLAST-FORMING ACTIVITY: I. TAXONOMY OF PRODUCING ORGANISMS AND FERMENTATION

A new peptide antibiotic, globomycin, was found to be produced by four different strains of the actinomycetes. They were identified as Streptomyces halstedii No. 13912, Streptoverticillium cinnamoneum No. 15037, Streptomyces neohygroscopicus subsp. globomyceticus No. 15631 and Streptomyces hagronens...

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Bibliographic Details
Published in:Journal of antibiotics 1978, Vol.31(5), pp.410-420
Main Authors: INUKAI, MASATOSHI, ENOKITA, RYUZO, TORIKATA, AKIO, NAKAHARA, MASAKI, IWADO, SEIGO, ARAI, MAMORU
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - biosynthesis
Anti-Bacterial Agents - pharmacology
Fermentation
Peptide Biosynthesis
Peptides - pharmacology
Spheroplasts - drug effects
Streptomyces - classification
Streptomyces - metabolism
Time Factors
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Summary:A new peptide antibiotic, globomycin, was found to be produced by four different strains of the actinomycetes. They were identified as Streptomyces halstedii No. 13912, Streptoverticillium cinnamoneum No. 15037, Streptomyces neohygroscopicus subsp. globomyceticus No. 15631 and Streptomyces hagronensis No. 17834, respectively. Fermentation of globomycin was conducted by conventional submerged culture for antibiotic production, in which 10 μg/ml of globomycin was produced by cultivation of S. halstedii No. 13912 for 96 hours at 27°C. Globomycin was named after its activity to form global-shape spheroplasts when Escherichia coli was incubated in the presence of this antibiotic.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.31.410