Exchangeable sodium and saralasin-blocking, plasma renin and aldosterone in pre- and postoperative young patients with aortic coarctation

• Published in: European heart journal 1982-04, Vol.3 (2), p.179-183
• Main Authors: SEHESTED, J., KORNERUP, H. J., PEDERSEN, E. B.
• Format: Article
• Language: English
• Subjects: Adolescent; aldosterone; Aldosterone - blood; Angiotensin II - analogs & derivatives; Aortic Coarctation - blood; Aortic Coarctation - surgery; Child; Coarctation; exchangeable sodium; Humans; Hypertension - etiology; Natriuresis; Postoperative Period; renin; Renin - blood; Renin-Angiotensin System; saralasin; Saralasin - antagonists & inhibitors
• ISSN: 0195-668X; 1522-9645
• DOI: 10.1093/oxfordjournals.eurheartj.a061282

In a group of eight children (mean age 12 years), all with an uncomplicated aortic coarctation, values of exchangeable sodium, plasma renin activity and plasma aldosterone were determined following administration of furosemide before and on average 138 days after surgical correction. The saralasin test was performed upon six patients before and five after operation. No statistically significant differences were found between pre- and postoperative values of exchangeable sodium and hormones. There was no correlation between these parameters and blood pressures. Only one patient, on treatment with an anabolic steroid because of Turner's syndrome, showed a depressor response to the pre-operative saralasin test. No reactions were seen in any of the patients after operation. The study does not lend support to the idea of a ‘masked’ renal origin of coarctational hypertension due to an increased fluid volume.