STUDIES ON THE THERAPEUTICS OF EXPERIMENTAL TOXOPLASMOSIS: II. EFFECT OF ACETYLSPIRAMYCIN ALONE OR IN COMBINATION WITH AN IMMUNOPOTENTIATOR(CSP-II)OR SULFAMETHOPYRAZINE ON TOXOPLASMA MULTIPLICATION IN THE HEART OF MICE ACUTELY AND CHRONICALLY INFECTED WITH TOXOPLASMA GONDII

Normal mice acutely and chronically infected with the S-273 strain of T.gondii, were treated with acetylspiramycin (ASPM) alone, 8 mg/mouse/day, per os, or in combination with an immunopotentiator (CSP-II), 10 mg/mouse/day, intraperitoneally, or sulfamethopyrazine (SMPZ), 2mg/mouse/day, per os, for...

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Published in:Japanese journal of antibiotics 1982/02/25, Vol.35(2), pp.362-368
Main Authors: ESPINAS, F.M., TAKEI, YOSHIMI, SAKURAI, HARUHISA, ODAKURA, YOSHIHIRO, SUZUKI, NAOYOSHI, SASAKI, HIROSHI
Format: Article
Language:Japanese
Subjects:
Adjuvants, Immunologic - administration & dosage
Animals
Brain - parasitology
Drug Therapy, Combination
Female
Heart - parasitology
Leucomycins - administration & dosage
Male
Mice
Mice, Inbred Strains
Spiramycin - analogs & derivatives
Sulfamethoxypyridazine - administration & dosage
Toxoplasma - growth & development
Toxoplasmosis, Animal - drug therapy
Toxoplasmosis, Animal - parasitology
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Summary:Normal mice acutely and chronically infected with the S-273 strain of T.gondii, were treated with acetylspiramycin (ASPM) alone, 8 mg/mouse/day, per os, or in combination with an immunopotentiator (CSP-II), 10 mg/mouse/day, intraperitoneally, or sulfamethopyrazine (SMPZ), 2mg/mouse/day, per os, for a period of 4 weeks. In the acute cases, a 99.4% cyst reduction was obtained with ASPM alone and no cysts were seen in the brains of mice treated with ASPM in combination with CSP-II or SMPZ.The organisms were significantly eradicated in the brain and heart tissues of mice trated with ASPM alone or in combination with CSP-II or SMPZ as shown by subinoculation to normal mice and the negative latex hemagglutination titers of the recipient mice. In the chronic cases, a cyst reduction of 52.4% was obtained with mice treated with ASPM in combination with ap-n.A cyst reduction of 34.6%, 32.9% and 20.8% was obtained in the ASPM alone, CSP-II alone and ASPM in combination with SMPZ treated groups, respectively.A comparative clearing of the organisms in the heart tissues of mice treated with ASPM in combination with CSP-Hwas obtained compared to the other treatment groups but not in the brains of all groups.
ISSN:0368-2781
2186-5477
DOI:10.11553/antibiotics1968b.35.362