SQ 26, 180, A NOVEL MONOBACTAM. II: ISOLATION, STRUCTURE DETERMINATION AND SYNTHESIS

A novel monocyclic β-lactam antibiotic SQ 26, 180 has been isolated from bacteria and the structure, (R)-3-acetylamino-3-methoxy-2-oxo-1-azetidinesulfonic acid was deduced from its spectroscopic properties. Structural confirmation and assignment of absolute configuration were made by synthesis from...

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Bibliographic Details
Published in:Journal of antibiotics 1982, Vol.35(2), pp.189-195
Main Authors: PARKER, WILLIAM L., KOSTER, WILLIAM H., CIMARUSTI, CHRISTOPHER M., FLOYD, DAVID M., LIU, WEN-CHIH, RATHNUM, MARLENE
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - isolation & purification
Aztreonam - analogs & derivatives
Chemical Phenomena
Chemistry
Chromobacterium - metabolism
Lactams - isolation & purification
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Summary:A novel monocyclic β-lactam antibiotic SQ 26, 180 has been isolated from bacteria and the structure, (R)-3-acetylamino-3-methoxy-2-oxo-1-azetidinesulfonic acid was deduced from its spectroscopic properties. Structural confirmation and assignment of absolute configuration were made by synthesis from 6-aminopenicillanic acid.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.35.189