A Glucagon‐secreting alpha‐cell carcinoma of the pancreas

A case of alpha‐cell carcinoma of the pancreas with classic manifestations of glucagonoma syndrome and hepatic metastasis is reported. A diagnosis of glucagonoma was made by the characteristic dermatological findings of necrolytic migratory erythema and hyperglucagonemia. Operative removal of the me...

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Bibliographic Details
Published in:World journal of surgery 1982-01, Vol.6 (1), p.107-109
Main Authors: Goto, Hiraaki, Yamaji, Yoichi, Konno, Toshimitsu, Murata, Etsuo, Tashiro, Seiki, Yokoyama, Ikuzo
Format: Article
Language:English
Subjects:
Adenoma, Islet Cell - diagnosis
Erythema - etiology
Female
Glucagon
Glucagonoma - complications
Glucagonoma - diagnosis
Hepatic Metastasis
Humans
Liver Neoplasms - secondary
Metastatic Tumor
Middle Aged
Pancreatic Neoplasms - complications
Pancreatic Neoplasms - diagnosis
Skin Rash
Syndrome Typique
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Summary:A case of alpha‐cell carcinoma of the pancreas with classic manifestations of glucagonoma syndrome and hepatic metastasis is reported. A diagnosis of glucagonoma was made by the characteristic dermatological findings of necrolytic migratory erythema and hyperglucagonemia. Operative removal of the metastatic tumors resulted in rapid regression of the skin rash and hyperglucagonemia. But a primary focus 1 cm in diameter, with central necrosis, had been left in the head of the pancreas. This was verified by autopsy. Résumé Cet article rapporte un cas de glucagonome malin caractérisé par un syndrome typique et des metastases hépatiques. Le diagnostic fut porté sur la constatation d'un érythème nécrolytique migrateur et le taux élevé du glucagon. L'exérèse des metastases hépatiques entraina la régression rapide des lésions cutanées et de l'hyperglucagonémie mais le foyer primitif de 1 cm de diamètre, nécrosé en son centre et laissé en place au niveau du segment céphalique du pancréas entraina finalement la mort. Il fut découvert à l'autopsie.
ISSN:0364-2313
1432-2323
DOI:10.1007/BF01656382