Relationships between steroid receptor and epithelial cell proliferation in benign fibrocystic disease of the breast

Tissue specimens from 27 patients with mammary fibrocystic disease were assayed for estrogen (ER) and progestin (PR) receptors. Seventeen patients (63%) had ER‐positive lesions (>5 fmol/mg protein). A progression in ER presence was noted from fibrocystic disease (33%) and fibrosing adenosis (50%)...

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Bibliographic Details
Published in:Cancer 1982-06, Vol.49 (12), p.2534-2536
Main Authors: Jacquemier, Jocelyne D., Rolland, Pierre H., Vague, Daniele, Lieutaud, Roger, Spitalier, Jean M., Martin, Pierre M.
Format: Article
Language:English
Subjects:
Adult
Breast Diseases
Cell Division
Epithelium - pathology
Female
Fibrocystic Breast Disease - analysis
Fibrocystic Breast Disease - pathology
Humans
Hyperplasia
Middle Aged
Receptors, Estrogen - analysis
Receptors, Progesterone - analysis
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Summary:Tissue specimens from 27 patients with mammary fibrocystic disease were assayed for estrogen (ER) and progestin (PR) receptors. Seventeen patients (63%) had ER‐positive lesions (>5 fmol/mg protein). A progression in ER presence was noted from fibrocystic disease (33%) and fibrosing adenosis (50%) to lobular and ductal hyperplasia (85%). Similarly, ER content increased from 14.5 ± 13 fmol/mg cytosol protein in fibrocystic disease and fibrosing adenosis to 31.5 ± 23 fmol/mg protein in epithelial hyperplastic lesions. Furthermore, the ER‐PR couple was only encountered in lobular and ductal hyperplasia. The authors' data indicate that the incidence of steroid receptor parallels the intensity of hyperplasia in benign breast disease.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19820615)49:12<2534::AID-CNCR2820491221>3.0.CO;2-J