Oxytocin, Vasopressin, and Estrogen-Stimulated Neurophysin: Daily Patterns of Concentration in Cerebrospinal Fluid

The concentrations of oxytocin, arginine vasopressin, and estrogenstimulated neurophysin in cerebrospinal fluid of monkeys showed a daily fluctuation with high concentrations occurring during the light period. The patterns of oxytocin and estrogen-stimulated neurophysin in the cerebrospinal fluid we...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1982-06, Vol.216 (4553), p.1416-1418
Main Authors: Perlow, M. J., Reppert, S. M., Artman, H. A., Fisher, D. A., Seif, S. M., Robinson, A. G.
Format: Article
Language:English
Subjects:
Animals
Arginine Vasopressin - blood
Arginine Vasopressin - cerebrospinal fluid
Blood
Blood plasma
Carrier proteins
Cerebrospinal fluid
Circadian Rhythm
Endocrinology
Estradiol - pharmacology
Hormone research
Kimchi
Macaca mulatta
Male
Male animals
Neurons
Neurons, Efferent - metabolism
Neurophysins
Neurophysins - cerebrospinal fluid
Oxytocin
Oxytocin - blood
Oxytocin - cerebrospinal fluid
Phosphates
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Summary:The concentrations of oxytocin, arginine vasopressin, and estrogenstimulated neurophysin in cerebrospinal fluid of monkeys showed a daily fluctuation with high concentrations occurring during the light period. The patterns of oxytocin and estrogen-stimulated neurophysin in the cerebrospinal fluid were not observed in the plasma nor were they altered after the administration of a dose of estradiol that increased concentrations of estrogen-stimulated neurophysin in plasma. The disassociation between these cerebrospinal fluid and plasma patterns and values suggests that the secretory activity of neurons that release estrogen-stimulated neurophysin and oxytocin into the cerebrospinal fluid is controlled by mechanisms different from those that control their release into the plasma.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.7201163