The effect of alinidine (St 567) on emotionally induced tachycardia in man

Experiments were performed in a randomized double-blind cross-over study in 6 healthy volunteers to answer the question if alinidine, a new analogue of clonidine with a bradycardic effect directly on the sinus node, would have an effect on an emotionally-induced tachycardia. Alinidine 40 mg orally s...

Full description

Saved in:
Bibliographic Details
Published in:European journal of clinical pharmacology 1982-01, Vol.21 (6), p.467-471
Main Authors: Auböck, J, Konzett, H, Olbrich, E
Format: Article
Language:English
Subjects:
Adult
Blood Pressure - drug effects
Clonidine - analogs & derivatives
Clonidine - therapeutic use
Drug Evaluation
Heart Rate - drug effects
Humans
Male
Stress, Psychological - complications
Tachycardia - drug therapy
Tachycardia - etiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Experiments were performed in a randomized double-blind cross-over study in 6 healthy volunteers to answer the question if alinidine, a new analogue of clonidine with a bradycardic effect directly on the sinus node, would have an effect on an emotionally-induced tachycardia. Alinidine 40 mg orally significantly (1%) reduced the tachycardia and the concomitant rise in diastolic blood pressure during the stress of performing a mental task. Forearm blood flow and the efficiency (total score in the mental task) remained unchanged by alinidine.
ISSN:0031-6970
1432-1041
DOI:10.1007/BF00542040