The effect of alinidine (St 567) on emotionally induced tachycardia in man

Experiments were performed in a randomized double-blind cross-over study in 6 healthy volunteers to answer the question if alinidine, a new analogue of clonidine with a bradycardic effect directly on the sinus node, would have an effect on an emotionally-induced tachycardia. Alinidine 40 mg orally s...

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Published in:European journal of clinical pharmacology 1982-01, Vol.21 (6), p.467-471
Main Authors: Auböck, J, Konzett, H, Olbrich, E
Format: Article
Language:English
Subjects:
Adult
Blood Pressure - drug effects
Clonidine - analogs & derivatives
Clonidine - therapeutic use
Drug Evaluation
Heart Rate - drug effects
Humans
Male
Stress, Psychological - complications
Tachycardia - drug therapy
Tachycardia - etiology
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creator Auböck, J
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Olbrich, E
description Experiments were performed in a randomized double-blind cross-over study in 6 healthy volunteers to answer the question if alinidine, a new analogue of clonidine with a bradycardic effect directly on the sinus node, would have an effect on an emotionally-induced tachycardia. Alinidine 40 mg orally significantly (1%) reduced the tachycardia and the concomitant rise in diastolic blood pressure during the stress of performing a mental task. Forearm blood flow and the efficiency (total score in the mental task) remained unchanged by alinidine.
doi_str_mv 10.1007/BF00542040
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identifier ISSN: 0031-6970
ispartof European journal of clinical pharmacology, 1982-01, Vol.21 (6), p.467-471
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source Springer Online Journal Archives (Through 1996)
subjects Adult
Blood Pressure - drug effects
Clonidine - analogs & derivatives
Clonidine - therapeutic use
Drug Evaluation
Heart Rate - drug effects
Humans
Male
Stress, Psychological - complications
Tachycardia - drug therapy
Tachycardia - etiology
title The effect of alinidine (St 567) on emotionally induced tachycardia in man
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