Physiologic saline solution, Normosol R pH 7.4, and Plasmanate as reconstituents of packed human erythrocytes

The authors compared the effects of three reconstituent solutions (Normosol R pH 7.4, physiologic saline solution, and Plasmanate) on hemolysis and cellular morphology of young (8-10 days' storage) and old (22-26 days' storage) packed human erythrocytes (PE). These variables were tested at...

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Bibliographic Details
Published in:Anesthesiology (Philadelphia) 1978-08, Vol.49 (2), p.99-101
Main Authors: Brown, W J, Kim, B S, Weeks, D B, Parkin, C E
Format: Article
Language:English
Subjects:
Blood Proteins
Blood Transfusion
Erythrocyte Transfusion
Hemolysis
Humans
Plasma Substitutes
Sodium Chloride
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Summary:The authors compared the effects of three reconstituent solutions (Normosol R pH 7.4, physiologic saline solution, and Plasmanate) on hemolysis and cellular morphology of young (8-10 days' storage) and old (22-26 days' storage) packed human erythrocytes (PE). These variables were tested at 22 and 37 C and at two dilutions )1 part PE:1 part reconstituent and 2 parts PE:1 part reconstituent). Plasmanate produced unacceptably high levels of hemolysis, particularly of older PE, and should not be used as a reconstituent. Normosol R pH 7.4 and physiologic saline solution were compatible with both young and old PE, producing similar changes in hemolysis and erythrocytic morphology, Therefore, Normosol R pH 7.4 may be used as a diluent for PE when rapid and massive infusions are needed.
ISSN:0003-3022
DOI:10.1097/00000542-197808000-00008