Establishment and characterization of three new continuous cell lines derived from human breast carcinomas

Three continuous lines of mammary tumor cells (ZR-75-1, ZR-75-27, and ZR-75-30) have been established from malignant effusions of two women with breast cancer. Differentiated properties expressed by each cell line include: (a) epithelial morphology (by light and electron microscopy) resembling that...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1978-10, Vol.38 (10), p.3352-3364
Main Authors: Engel, L W, Young, N A, Tralka, T S, Lippman, M E, O'Brien, S J, Joyce, M J
Format: Article
Language:English
Subjects:
Breast Neoplasms - genetics
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Caseins - biosynthesis
Cell Division
Cell Line
Chromosome Aberrations
Female
Humans
Kinetics
Lactalbumin - biosynthesis
Microscopy, Electron
Neoplasms, Experimental - pathology
Neoplasms, Hormone-Dependent - metabolism
Receptors, Steroid
Thymidine - metabolism
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Summary:Three continuous lines of mammary tumor cells (ZR-75-1, ZR-75-27, and ZR-75-30) have been established from malignant effusions of two women with breast cancer. Differentiated properties expressed by each cell line include: (a) epithelial morphology (by light and electron microscopy) resembling that of the parental tumors; (b) presence of receptors for estrogen and other steroid hormones; and (c) growth responsiveness to estrogen and/or progesterone. All three cell lines possess human karyotypes that differ from one another in modal chromosome number as well as in characteristic marker chromosomes. Two of the cultures (ZR-75-27 and ZR-75-30), although derived from the same patient, have stable differences in their karyotypes.
ISSN:0008-5472