Structural and immunological studies of the Escherichia coli K7 (K56) capsular polysaccharide

The structure of the Escherichia coli K7 capsular polysaccharide has been investigated by a combination of chemical and spectroscopic methods. The structure of the repeating unit of the polymer was found to be →3)-β- d-ManNAcA-(1→4)-β- d-Glc-(1→; the O-6 atom of the d-glucosyl residue in the repeati...

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Bibliographic Details
Published in:Carbohydrate research 1982-04, Vol.102 (1), p.263-271
Main Authors: Tsui, Fai-Po, Boykins, Robert A., Egan, William
Format: Article
Language:English
Subjects:
Carbohydrate Conformation
Carbohydrate Sequence
Cross Reactions
Escherichia coli - immunology
Polysaccharides, Bacterial - immunology
Species Specificity
Streptococcus pneumoniae - immunology
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Summary:The structure of the Escherichia coli K7 capsular polysaccharide has been investigated by a combination of chemical and spectroscopic methods. The structure of the repeating unit of the polymer was found to be →3)-β- d-ManNAcA-(1→4)-β- d-Glc-(1→; the O-6 atom of the d-glucosyl residue in the repeating unit is acetylated. The K7 polysaccharide is cross-reactive with the Streptococcus pneumoniae type 3 polysaccharide, the structure of which had previously been determined; our n.m.r. studies of the S. pneumoniae type 3 polysaccharide are in accord with this structure. The E. coli K7 and K56 capsular antigens have been shown by serology and 13C-n.m.r. spectroscopy to be identical.
ISSN:0008-6215
1873-426X
DOI:10.1016/S0008-6215(00)88068-4