Effect of sodium cis-beta-4-methoxybenzoyl-beta-bromacrylate (Cytembena) on HeLa cell kinetics

The treatment of HeLa cells with various concentrations of sodium beta-4-methoxybenzoyl-beta-bromacrylate (Cytembena) results in inhibition of growth and modification of cell cycle distribution. These phenomena were observed at concentrations between 7.5 x 10(-5) and 2.5 x 10(-5) M. The estimation o...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1982-08, Vol.42 (8), p.3193-3195
Main Authors: Ronot, X, Adolphe, M, Kuch, D, Jaffray, P, Lechat, P, Deysson, G
Format: Article
Language:English
Subjects:
Acrylates - pharmacology
Cell Cycle - drug effects
HeLa Cells - drug effects
HeLa Cells - physiology
Humans
Interphase - drug effects
Kinetics
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Summary:The treatment of HeLa cells with various concentrations of sodium beta-4-methoxybenzoyl-beta-bromacrylate (Cytembena) results in inhibition of growth and modification of cell cycle distribution. These phenomena were observed at concentrations between 7.5 x 10(-5) and 2.5 x 10(-5) M. The estimation of DNA content by flow cytometry showed an important shift in the distribution of cycling cells with a relative decrease of G0 + G1 cells and a striking accumulation of G2 + M cells. According to our experimental conditions, the blocking up in G2 + M is irreversible at 7.5 and 5 x 10(-5) M.
ISSN:0008-5472