Assignment of peptidase S (PEPS) to chromosome 4 in man using somatic cell hybrids

A starch gel electrophoretic procedure is described that resolves peptidase S (PEPS) as well as the peptidases A, B, and C in man-rodent, rodent-rodent, and primate-rodent interspecific somatic cell hybrids. The interspecific PEPS cell hybrid phenotype can be resolved into a pattern which suggests t...

Full description

Saved in:
Bibliographic Details
Published in:Human genetics 1978-01, Vol.43 (2), p.119-125
Main Authors: Shows, T B, Brown, J A, Eddy, R L, Byers, M G, Haley, L L, Cooper, E S, Goggin, A P
Format: Article
Language:English
Subjects:
Aminopeptidases - genetics
Animals
Chromosomes, Human, 4-5
Cricetinae
Electrophoresis, Starch Gel
Genes
Genetic Linkage
Humans
Hybrid Cells
Mice
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A starch gel electrophoretic procedure is described that resolves peptidase S (PEPS) as well as the peptidases A, B, and C in man-rodent, rodent-rodent, and primate-rodent interspecific somatic cell hybrids. The interspecific PEPS cell hybrid phenotype can be resolved into a pattern which suggests that PEPS is composed of five or six identical subunits. Results are presented supporting assignment of the PEPS locus to chromosome 4 in man using man-mouse and man-Chinese hamster somatic cell hybrids. Human genes coding for peptidases A, B, C, and D were assigned to chromosome 18, 12, 1, and 19, respectively, confirming previous assignments. These somatic cell genetic data demonstrate the independent genetic control of the several human peptidases.
ISSN:0340-6717
1432-1203
DOI:10.1007/BF00293588