Formation of Hydrotalcite in Mixtures of Aluminum Hydroxycarbonate and Magnesium Hydroxide Gels

IR and X-ray analysis demonstrate that hydrotalcite forms during the aging of aluminum hydroxycarbonate gel and magnesium hydroxide gel mixtures. The formation of hydrotalcite produces a change in the pH-stat titrigram and a sharp increase in the pH of the mixture. Hydrotalcite was noted earlier in...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1982-07, Vol.71 (7), p.780-786
Main Authors: Vanderlaan, Roger K., White, Joe L., Hem, Stanley L.
Format: Article
Language:English
Subjects:
Aluminum Hydroxide - analysis
Chemistry, Pharmaceutical
Drug Combinations
formation of hydrotalcite
Gels-aluminum hydroxycarbonate and magnesium hydroxide gels
Gels—aluminum hydroxycarbonate and magnesium hydroxide gels mixtures, formation of hydrotalcite
Hydrogen-Ion Concentration
Hydrotalcite-formation
Hydrotalcite—formation mixtures of aluminum hydroxycarbonate and magnesium hydroxide gels, IR and X-ray analysis
IR and X-ray analysis
Magnesium - analysis
Magnesium Hydroxide - analysis
mixtures
mixtures of aluminum hydroxycarbonate and magnesium hydroxide gels
Mixtures-formation of hydrotalcite in mixtures of aluminum hydroxycarbonate and magnesium hydroxide gels
Spectrophotometry, Infrared
Time Factors
X-Ray Diffraction
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Summary:IR and X-ray analysis demonstrate that hydrotalcite forms during the aging of aluminum hydroxycarbonate gel and magnesium hydroxide gel mixtures. The formation of hydrotalcite produces a change in the pH-stat titrigram and a sharp increase in the pH of the mixture. Hydrotalcite was noted earlier in mixtures having a high molar ratio of magnesium to aluminum, a high total gel concentration, a high initial pH, or in mixtures stored at elevated temperatures. The addition of sorbitol to the mixtures substantially delayed the appearance of hydrotalcite. Nonacid-reactive hydrotalcite formed when mixtures of chloride-containing aluminum hydroxide gel and magnesium hydroxide gel were aged.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600710715