Pharmacokinetics of fluorouracil in humans

A high-pressure liquid chromatography method has been used to investigate the pharmacokinetics of fluorouracil after single i.v. doses to patients. The method is simple and is specific for fluorouracil. No interference was observed in fluorouracil determinations due to other administered medication....

Full description

Saved in:
Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1978-10, Vol.38 (10), p.3479-3482
Main Authors: MacMillan, W E, Wolberg, W H, Welling, P G
Format: Article
Language:English
Subjects:
Adult
Aged
Female
Fluorouracil - administration & dosage
Fluorouracil - blood
Half-Life
Humans
Injections, Intravenous
Male
Metabolic Clearance Rate
Middle Aged
Models, Biological
Neoplasms - blood
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A high-pressure liquid chromatography method has been used to investigate the pharmacokinetics of fluorouracil after single i.v. doses to patients. The method is simple and is specific for fluorouracil. No interference was observed in fluorouracil determinations due to other administered medication. Plasma levels of fluorouracil declined rapidly after dosing. The mean half-life was 11.4 min, and drug was essentially cleared from plasma in 1 hr. Individual differences in plasma fluorouracil levels, and also in derived pharmacokinetic constants, were considerably less than those reported previously.
ISSN:0008-5472