Growth Inhibition of Transformed Cells with Succinylated Concanavalin A

Succinylated concanavalin A reversibly inhibits the growth of SV40 transformed mouse 3T3 cells and thus causes an accumulation of the cells in the G$_{1}$ phase of the cell cycle. In a soft substrate (methylcellulose) succinylated concanavalin A also restores in transformed cells the growth behavior...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1978-09, Vol.201 (4358), p.824-826
Main Authors: Mannino, Raphael J., Ballmer, Kurt, Burger, Max M.
Format: Article
Language:English
Subjects:
3T3 cells
Cell Adhesion - drug effects
Cell cycle
Cell Cycle - drug effects
Cell growth
Cell Line
Cell lines
Cell Transformation, Neoplastic - drug effects
Concanavalin A - analogs & derivatives
Concanavalin A - pharmacology
Daughter cells
Growth inhibitors
Interphase
Kidney cells
Liver
Simian virus 40
Succinates
Transformed cell line
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Summary:Succinylated concanavalin A reversibly inhibits the growth of SV40 transformed mouse 3T3 cells and thus causes an accumulation of the cells in the G$_{1}$ phase of the cell cycle. In a soft substrate (methylcellulose) succinylated concanavalin A also restores in transformed cells the growth behavior typical of untransformed cells.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.210502