Growth Inhibition of Transformed Cells with Succinylated Concanavalin A

Succinylated concanavalin A reversibly inhibits the growth of SV40 transformed mouse 3T3 cells and thus causes an accumulation of the cells in the G$_{1}$ phase of the cell cycle. In a soft substrate (methylcellulose) succinylated concanavalin A also restores in transformed cells the growth behavior...

Full description

Saved in:
Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1978-09, Vol.201 (4358), p.824-826
Main Authors: Mannino, Raphael J., Ballmer, Kurt, Burger, Max M.
Format: Article
Language:English
Subjects:
3T3 cells
Cell Adhesion - drug effects
Cell cycle
Cell Cycle - drug effects
Cell growth
Cell Line
Cell lines
Cell Transformation, Neoplastic - drug effects
Concanavalin A - analogs & derivatives
Concanavalin A - pharmacology
Daughter cells
Growth inhibitors
Interphase
Kidney cells
Liver
Simian virus 40
Succinates
Transformed cell line
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c340t-2df5848c7cf5c6cc1ed89aa17010f5a7531c993bb9380da0cb47cb9f5aa7787f3
cites cdi_FETCH-LOGICAL-c340t-2df5848c7cf5c6cc1ed89aa17010f5a7531c993bb9380da0cb47cb9f5aa7787f3
container_end_page 826
container_issue 4358
container_start_page 824
container_title Science (American Association for the Advancement of Science)
container_volume 201
creator Mannino, Raphael J.
Ballmer, Kurt
Burger, Max M.
description Succinylated concanavalin A reversibly inhibits the growth of SV40 transformed mouse 3T3 cells and thus causes an accumulation of the cells in the G$_{1}$ phase of the cell cycle. In a soft substrate (methylcellulose) succinylated concanavalin A also restores in transformed cells the growth behavior typical of untransformed cells.
doi_str_mv 10.1126/science.210502
format article
fullrecord <record><control><sourceid>jstor_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_74145616</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>1746144</jstor_id><sourcerecordid>1746144</sourcerecordid><originalsourceid>FETCH-LOGICAL-c340t-2df5848c7cf5c6cc1ed89aa17010f5a7531c993bb9380da0cb47cb9f5aa7787f3</originalsourceid><addsrcrecordid>eNpdkL1PwzAQxS3EVymsTAyZ2FLOsR0nY1VBqVSJgTJHzsVWXaV2sVNQ_3tSpQKJ6aR7v3u69wi5pzChNMufIlrtUE8yCgKyMzKiUIq0zICdkxEAy9MCpLgmNzFuAHqtZFfkcqBHZD4P_rtbJwu3trXtrHeJN8kqKBeND1vdJDPdtjH5tj30vke07tCq7rj3DpVTX6q1Lpnekguj2qjvTnNMPl6eV7PXdPk2X8ymyxQZhy7NGiMKXqBEIzBHpLopSqWoBApGKCkYxbJkdV2yAhoFWHOJddlLSspCGjYmj4PvLvjPvY5dtbUR-xeV034fK8kpFznNe3AygBh8jEGbahfsVoVDRaE6FlediquGKvqDh5Pzvu5z_-L_5U3sfPgzkzynnLMf5_10Eg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>74145616</pqid></control><display><type>article</type><title>Growth Inhibition of Transformed Cells with Succinylated Concanavalin A</title><source>Science Online_科学在线</source><creator>Mannino, Raphael J. ; Ballmer, Kurt ; Burger, Max M.</creator><creatorcontrib>Mannino, Raphael J. ; Ballmer, Kurt ; Burger, Max M.</creatorcontrib><description>Succinylated concanavalin A reversibly inhibits the growth of SV40 transformed mouse 3T3 cells and thus causes an accumulation of the cells in the G$_{1}$ phase of the cell cycle. In a soft substrate (methylcellulose) succinylated concanavalin A also restores in transformed cells the growth behavior typical of untransformed cells.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.210502</identifier><identifier>PMID: 210502</identifier><language>eng</language><publisher>United States: American Association for the Advancement of Science</publisher><subject>3T3 cells ; Cell Adhesion - drug effects ; Cell cycle ; Cell Cycle - drug effects ; Cell growth ; Cell Line ; Cell lines ; Cell Transformation, Neoplastic - drug effects ; Concanavalin A - analogs &amp; derivatives ; Concanavalin A - pharmacology ; Daughter cells ; Growth inhibitors ; Interphase ; Kidney cells ; Liver ; Simian virus 40 ; Succinates ; Transformed cell line</subject><ispartof>Science (American Association for the Advancement of Science), 1978-09, Vol.201 (4358), p.824-826</ispartof><rights>Copyright 1978 American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c340t-2df5848c7cf5c6cc1ed89aa17010f5a7531c993bb9380da0cb47cb9f5aa7787f3</citedby><cites>FETCH-LOGICAL-c340t-2df5848c7cf5c6cc1ed89aa17010f5a7531c993bb9380da0cb47cb9f5aa7787f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2884,2885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/210502$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mannino, Raphael J.</creatorcontrib><creatorcontrib>Ballmer, Kurt</creatorcontrib><creatorcontrib>Burger, Max M.</creatorcontrib><title>Growth Inhibition of Transformed Cells with Succinylated Concanavalin A</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Succinylated concanavalin A reversibly inhibits the growth of SV40 transformed mouse 3T3 cells and thus causes an accumulation of the cells in the G$_{1}$ phase of the cell cycle. In a soft substrate (methylcellulose) succinylated concanavalin A also restores in transformed cells the growth behavior typical of untransformed cells.</description><subject>3T3 cells</subject><subject>Cell Adhesion - drug effects</subject><subject>Cell cycle</subject><subject>Cell Cycle - drug effects</subject><subject>Cell growth</subject><subject>Cell Line</subject><subject>Cell lines</subject><subject>Cell Transformation, Neoplastic - drug effects</subject><subject>Concanavalin A - analogs &amp; derivatives</subject><subject>Concanavalin A - pharmacology</subject><subject>Daughter cells</subject><subject>Growth inhibitors</subject><subject>Interphase</subject><subject>Kidney cells</subject><subject>Liver</subject><subject>Simian virus 40</subject><subject>Succinates</subject><subject>Transformed cell line</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><recordid>eNpdkL1PwzAQxS3EVymsTAyZ2FLOsR0nY1VBqVSJgTJHzsVWXaV2sVNQ_3tSpQKJ6aR7v3u69wi5pzChNMufIlrtUE8yCgKyMzKiUIq0zICdkxEAy9MCpLgmNzFuAHqtZFfkcqBHZD4P_rtbJwu3trXtrHeJN8kqKBeND1vdJDPdtjH5tj30vke07tCq7rj3DpVTX6q1Lpnekguj2qjvTnNMPl6eV7PXdPk2X8ymyxQZhy7NGiMKXqBEIzBHpLopSqWoBApGKCkYxbJkdV2yAhoFWHOJddlLSspCGjYmj4PvLvjPvY5dtbUR-xeV034fK8kpFznNe3AygBh8jEGbahfsVoVDRaE6FlediquGKvqDh5Pzvu5z_-L_5U3sfPgzkzynnLMf5_10Eg</recordid><startdate>19780901</startdate><enddate>19780901</enddate><creator>Mannino, Raphael J.</creator><creator>Ballmer, Kurt</creator><creator>Burger, Max M.</creator><general>American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19780901</creationdate><title>Growth Inhibition of Transformed Cells with Succinylated Concanavalin A</title><author>Mannino, Raphael J. ; Ballmer, Kurt ; Burger, Max M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c340t-2df5848c7cf5c6cc1ed89aa17010f5a7531c993bb9380da0cb47cb9f5aa7787f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>3T3 cells</topic><topic>Cell Adhesion - drug effects</topic><topic>Cell cycle</topic><topic>Cell Cycle - drug effects</topic><topic>Cell growth</topic><topic>Cell Line</topic><topic>Cell lines</topic><topic>Cell Transformation, Neoplastic - drug effects</topic><topic>Concanavalin A - analogs &amp; derivatives</topic><topic>Concanavalin A - pharmacology</topic><topic>Daughter cells</topic><topic>Growth inhibitors</topic><topic>Interphase</topic><topic>Kidney cells</topic><topic>Liver</topic><topic>Simian virus 40</topic><topic>Succinates</topic><topic>Transformed cell line</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mannino, Raphael J.</creatorcontrib><creatorcontrib>Ballmer, Kurt</creatorcontrib><creatorcontrib>Burger, Max M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mannino, Raphael J.</au><au>Ballmer, Kurt</au><au>Burger, Max M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Growth Inhibition of Transformed Cells with Succinylated Concanavalin A</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1978-09-01</date><risdate>1978</risdate><volume>201</volume><issue>4358</issue><spage>824</spage><epage>826</epage><pages>824-826</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><abstract>Succinylated concanavalin A reversibly inhibits the growth of SV40 transformed mouse 3T3 cells and thus causes an accumulation of the cells in the G$_{1}$ phase of the cell cycle. In a soft substrate (methylcellulose) succinylated concanavalin A also restores in transformed cells the growth behavior typical of untransformed cells.</abstract><cop>United States</cop><pub>American Association for the Advancement of Science</pub><pmid>210502</pmid><doi>10.1126/science.210502</doi><tpages>3</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0036-8075
ispartof Science (American Association for the Advancement of Science), 1978-09, Vol.201 (4358), p.824-826
issn 0036-8075
1095-9203
language eng
recordid cdi_proquest_miscellaneous_74145616
source Science Online_科学在线
subjects 3T3 cells
Cell Adhesion - drug effects
Cell cycle
Cell Cycle - drug effects
Cell growth
Cell Line
Cell lines
Cell Transformation, Neoplastic - drug effects
Concanavalin A - analogs & derivatives
Concanavalin A - pharmacology
Daughter cells
Growth inhibitors
Interphase
Kidney cells
Liver
Simian virus 40
Succinates
Transformed cell line
title Growth Inhibition of Transformed Cells with Succinylated Concanavalin A
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T16%3A35%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Growth%20Inhibition%20of%20Transformed%20Cells%20with%20Succinylated%20Concanavalin%20A&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=Mannino,%20Raphael%20J.&rft.date=1978-09-01&rft.volume=201&rft.issue=4358&rft.spage=824&rft.epage=826&rft.pages=824-826&rft.issn=0036-8075&rft.eissn=1095-9203&rft_id=info:doi/10.1126/science.210502&rft_dat=%3Cjstor_proqu%3E1746144%3C/jstor_proqu%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c340t-2df5848c7cf5c6cc1ed89aa17010f5a7531c993bb9380da0cb47cb9f5aa7787f3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=74145616&rft_id=info:pmid/210502&rft_jstor_id=1746144&rfr_iscdi=true