Promoter-specific inhibition of transcription by antibiotics which act on DNA gyrase

Nalidixic acid, novobiocin and coumermycin specifically inhibit phage promoter-dependent transcription of the trp operon in Φ80 ptrp but not transcription from the authentic trp promoter. The nalidixic acid inhibition is not observed in an E. coli strain containing a nalA r mutation. These results i...

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Bibliographic Details
Published in:Nature (London) 1978-10, Vol.275 (5679), p.420-423
Main Authors: Smith, C. L, Kubo, M, Imamoto, F
Format: Article
Language:English
Subjects:
Coliphages - genetics
DNA Replication - drug effects
DNA-Directed RNA Polymerases - metabolism
Genes, Regulator - drug effects
Humanities and Social Sciences
multidisciplinary
Nalidixic Acid - pharmacology
Operon - drug effects
RNA, Messenger - biosynthesis
Science
Science (multidisciplinary)
Topoisomerase I Inhibitors
Transcription, Genetic - drug effects
Tryptophan - genetics
Virus Replication - drug effects
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Summary:Nalidixic acid, novobiocin and coumermycin specifically inhibit phage promoter-dependent transcription of the trp operon in Φ80 ptrp but not transcription from the authentic trp promoter. The nalidixic acid inhibition is not observed in an E. coli strain containing a nalA r mutation. These results indicate that DNA gyrase is involved in transcription.
ISSN:0028-0836
1476-4687
DOI:10.1038/275420a0