Influence of glomerular filtration rate on renal PAH secretion rate in the rat kidney. Dependency of PAH extraction on renal filtration fraction

PAH secretion (TPAH) was studied in rats at spontaneously occurring glomerular filtration rate (GFR). At saturated transport, TPAH was found to be correlated to GFR. This relationship was also observed at unsaturated transport where TPAH depends upon the PAH concentration in arterial plasma. However...

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Bibliographic Details
Published in:Pflügers Archiv 1978-07, Vol.375 (2), p.131-139
Main Authors: Häberle, D A, Ruhland, G, Lausser, A, Moore, L, Neiss, A
Format: Article
Language:English
Subjects:
Aminohippuric Acids - metabolism
Animals
Biological Transport
Glomerular Filtration Rate
Kidney - metabolism
Kidney Tubules - metabolism
Male
Osmolar Concentration
p-Aminohippuric Acid - metabolism
Rats
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Summary:PAH secretion (TPAH) was studied in rats at spontaneously occurring glomerular filtration rate (GFR). At saturated transport, TPAH was found to be correlated to GFR. This relationship was also observed at unsaturated transport where TPAH depends upon the PAH concentration in arterial plasma. However, no significant correlation between TPAH and renal PAH load or renal plasma flow rate was found when the effects of GFR were removed by partial correlation analysis. A dependency of TPAH on GFR explains the correlations found between filtration fraction (FF) and renal PAH extraction (EPAH) or renal tubular PAH extraction fraction (EPAH--FFPAH). Thus, even at low PAH concentration in a. plasma, renal PAH extraction may only be assumed to be constant if the filtration fraction is constant.
ISSN:0031-6768
1432-2013
DOI:10.1007/BF00584235