Determination of Related Compounds in Aspirin by Liquid Chromatography

A rapid liquid chromatographic procedure has been validated for the determination of salicylic acid, salsalate, acetylsalicylsali-cylic acid, and acetylsalicylic anhydride in aspirin. Samples are dissolved in methylene chloride and analyzed directly by adsorption chromatography in a 7-min separation...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1982-05, Vol.71 (5), p.511-514
Main Authors: Pfeiffer, C.D., Pankey, J.W.
Format: Article
Language:English
Subjects:
Aspirin - analogs & derivatives
Aspirin - analysis
Aspirin-determination of salicylic acid and related compounds by liquid chromatography
Chromatography, Liquid - methods
Liquid chromatography-determination of salicylic acid and related compounds in aspirin
related compounds
Salicylates - analysis
Salicylic Acid
Salicylic acid-determination in aspirin by liquid chromatography
Salicylic acid—determination in aspirin by liquid chromatography related compounds
Tablets - analysis
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Summary:A rapid liquid chromatographic procedure has been validated for the determination of salicylic acid, salsalate, acetylsalicylsali-cylic acid, and acetylsalicylic anhydride in aspirin. Samples are dissolved in methylene chloride and analyzed directly by adsorption chromatography in a 7-min separation using an isocratic mobile phase. Recoveries averaged 99% over a 200-10,000 ppm concentration range with standard deviations of
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600710508