Mucus Secretion-Stimulating Activity in Human Lymphoblastoid Cells

Two fractions isolated from cultured lymphoblastoid cells stimulated mucus secretion from the urn cell complex of the marine invertebrate Sipunculus nudus. The activity detected in the nuclear fraction was trypsin-sensitive, and it increased in response to specific nucleotides.

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1982-08, Vol.217 (4561), p.736-737
Main Authors: Kulemann-Kloene, H., Krag, S. S., Bang, F. B.
Format: Article
Language:English
Subjects:
Adults
Animals
Blood
Cell Fractionation
Cell Line
Cell lines
Cell Nucleus - analysis
Cultured cells
Cytoplasm - analysis
Deoxyribonuclease I
Deoxyribonucleases - pharmacology
Endonucleases - pharmacology
Humans
Leukocytes
Lymphocytes
Lymphocytes - metabolism
Marine
Mucous membrane
Mucus
Mucus - metabolism
Nematoda - metabolism
Nucleotides
Sipunculus nudus
T lymphocytes
Temperature
Transformed cell line
Trypsin - pharmacology
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Description
Summary:Two fractions isolated from cultured lymphoblastoid cells stimulated mucus secretion from the urn cell complex of the marine invertebrate Sipunculus nudus. The activity detected in the nuclear fraction was trypsin-sensitive, and it increased in response to specific nucleotides.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.6285469