In vivo effects of several anthracyclines on DNA integrity

Anthracycline antibiotics are widely used in human cancer chemotherapy. Their activity has been attributed mainly to their intercalation between the base pair of native DNA. In the last few years, however, a number of authors have attributed their cytotoxic action to DNA damage, such as single stran...

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Bibliographic Details
Published in:FEBS letters 1982-06, Vol.142 (1), p.17-22
Main Authors: Londos-Gagliardi, D., Aubel-Sadron, G.
Format: Article
Language:English
Subjects:
Animals
Antibiotics, Antineoplastic
Carcinoma, Ehrlich Tumor
Cell-Free System
Daunorubicin - pharmacology
DNA, Neoplasm
DNA, Single-Stranded
Drug Resistance
Mice
Naphthacenes - pharmacology
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Summary:Anthracycline antibiotics are widely used in human cancer chemotherapy. Their activity has been attributed mainly to their intercalation between the base pair of native DNA. In the last few years, however, a number of authors have attributed their cytotoxic action to DNA damage, such as single strand breaks or alkaline labile regions. Here, the authors report the results obtained with daunorubicin and some of its derivatives after administration of the drugs to mice bearing an Ehrlich ascites tumor. The sedimentation constant of the DNa has been determined in an analytical ultracentrifuge, before and after alkaline degradation and subsequently the number of single strand breaks has been calculated.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(82)80209-3