Cardiovascular adjustments to carbon monoxide exposure during rest and exercise in dogs

Cardiovascular, respiratory, and metabolic measurements were made on dogs at rest and during 30 minutes of exercise at either 6.4 km/hour, 10% grade, or 8.0 km/hour, 16% grade, following the bolus administration of CO for 1 or 2 minutes, or room-air breathing mixtures. During rest and exercise eleva...

Full description

Saved in:
Bibliographic Details
Published in:Environmental research 1978-06, Vol.15 (3), p.368-374
Main Authors: Wagner, Jeames A., Horvath, Steven M., Dahms, Thomas E.
Format: Article
Language:English
Subjects:
Animals
Carbon Monoxide - blood
Carboxyhemoglobin - metabolism
Cardiac Output
Dogs
Heart Rate
Hemodynamics
Male
Oxyhemoglobins - metabolism
Physical Exertion
Space life sciences
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cardiovascular, respiratory, and metabolic measurements were made on dogs at rest and during 30 minutes of exercise at either 6.4 km/hour, 10% grade, or 8.0 km/hour, 16% grade, following the bolus administration of CO for 1 or 2 minutes, or room-air breathing mixtures. During rest and exercise elevated mean blood HbCO levels (6 to 21%) reduced the arterial and mixed venous oxygen contents and saturations, and mixed venous P O 2 levels. Arterial-mixed venous oxygen differences were reduced during exercise as a result of CO administration. Elevated blood HbCO levels had a minimal or no effect on other cardiovascular, respiratory, and metabolic parameters. During work the reductions in a-v̄ O 2 differences were not offset by appropriate increases in cardiac outputs.
ISSN:0013-9351
1096-0953
DOI:10.1016/0013-9351(78)90118-4