Analysis of revertants of a ribosomal mutation in Podospora anserina: evidence for new ribosomal mutations which confer hypersensitivity to paromomycin

This paper describes the analysis of cold-resistant revertants of a cold-sensitive mutant. Pm1-1 is a ribosomal mutation screened for its paromomycin resistance. Suppression of its cold sensitivity occurs with two kinds of external mutations localized in two different loci. One of them, PmB, is assu...

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Bibliographic Details
Published in:Biochemical genetics 1982-06, Vol.20 (5-6), p.569-584
Main Authors: Randsholt, N, Ibarrondo, F, Dequard, M, Picard-Bennoun, M
Format: Article
Language:English
Subjects:
Ascomycota - drug effects
Ascomycota - genetics
Ascomycota - growth & development
Drug Resistance
Fungal Proteins - biosynthesis
Kinetics
Mutation
Paromomycin - pharmacology
Polyribosomes - metabolism
Protein Biosynthesis
Ribosomes - metabolism
Species Specificity
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Summary:This paper describes the analysis of cold-resistant revertants of a cold-sensitive mutant. Pm1-1 is a ribosomal mutation screened for its paromomycin resistance. Suppression of its cold sensitivity occurs with two kinds of external mutations localized in two different loci. One of them, PmB, is assumed to be a ribosomal gene. PmB mutations confer hypersensitivity to paromomycin in vivo as well as in vitro in a cell-free protein synthesis system.
ISSN:0006-2928
1573-4927
DOI:10.1007/BF00484705