ATRACURIUM: ITS SPEED OF ONSET. A COMPARISON WITH SUXAMETHONIUM

Forty healthy pauents were randomly selected to receive either atracurium 0 6 mg kg-1, or summethonium 1 mg kg-1. Onset of neuromuscular blockade and the time to full peripheral paralysis were measured using a train-of-four stimulus repeated once every 12 s. Atracurium appeared to be a potent non-de...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1982-09, Vol.54 (9), p.909-911
Main Authors: SCOTT, RALPH P.F., GOAT, VALERIE A.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Atracurium
Female
Heart Rate - drug effects
Humans
Isoquinolines - pharmacology
Male
Middle Aged
Muscle Contraction - drug effects
Neuromuscular Blocking Agents - pharmacology
Succinylcholine - pharmacology
Time Factors
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Summary:Forty healthy pauents were randomly selected to receive either atracurium 0 6 mg kg-1, or summethonium 1 mg kg-1. Onset of neuromuscular blockade and the time to full peripheral paralysis were measured using a train-of-four stimulus repeated once every 12 s. Atracurium appeared to be a potent non-depolanzmg muscle relaxant, with a rapid onset of action. However, full peripheral paralysis took longer to achieve than with suxamethonium. There were no significant problems with recovery.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/54.9.909