Iodophenylsulfonamide fatty acid analogs as potential myocardial imaging agents

Two phenylsulfonamide fatty acid analogs were synthesized and radioiodinated as potential myocardial imaging agents that might be taken up in the cells and metabolically trapped. The acids, N-11-( p-iodophenylsulfonamide)-undecanoic acid and N-12-( p-iodophenylsulfonamide)-dodecanoic acid, were radi...

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Bibliographic Details
Published in:The International journal of applied radiation and isotopes 1982-06, Vol.33 (6), p.451-453
Main Authors: Fritzberg, Alan R., Eshima, Dennis
Format: Article
Language:English
Subjects:
Animals
Heart - diagnostic imaging
Iodine Radioisotopes
Iodobenzenes - chemical synthesis
Iodobenzenes - metabolism
Isotope Labeling
Male
Mice
Radionuclide Imaging
Tissue Distribution
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Summary:Two phenylsulfonamide fatty acid analogs were synthesized and radioiodinated as potential myocardial imaging agents that might be taken up in the cells and metabolically trapped. The acids, N-11-( p-iodophenylsulfonamide)-undecanoic acid and N-12-( p-iodophenylsulfonamide)-dodecanoic acid, were radioiodinated by exchange with cupric sulfate catalysis. Tissue distribution studies of the radioiodinated acids were performed in mice. Negligible myocardial uptake and rapid renal excretion of the radio-activity was observed with both compounds. The results suggest that the sulfonamide group perturbs the fatty acids to the extent that myocardial uptake is prevented.
ISSN:0020-708X
DOI:10.1016/0020-708X(82)90046-1