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Iodophenylsulfonamide fatty acid analogs as potential myocardial imaging agents
Two phenylsulfonamide fatty acid analogs were synthesized and radioiodinated as potential myocardial imaging agents that might be taken up in the cells and metabolically trapped. The acids, N-11-( p-iodophenylsulfonamide)-undecanoic acid and N-12-( p-iodophenylsulfonamide)-dodecanoic acid, were radi...
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| Published in: | The International journal of applied radiation and isotopes 1982-06, Vol.33 (6), p.451-453 |
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| Main Authors: | , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c357t-d499220b21f5cb7370df860f953f5512e57ada1664f9cef2769eb51ffd1db4523 |
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| cites | cdi_FETCH-LOGICAL-c357t-d499220b21f5cb7370df860f953f5512e57ada1664f9cef2769eb51ffd1db4523 |
| container_end_page | 453 |
| container_issue | 6 |
| container_start_page | 451 |
| container_title | The International journal of applied radiation and isotopes |
| container_volume | 33 |
| creator | Fritzberg, Alan R. Eshima, Dennis |
| description | Two phenylsulfonamide fatty acid analogs were synthesized and radioiodinated as potential myocardial imaging agents that might be taken up in the cells and metabolically trapped. The acids,
N-11-(
p-iodophenylsulfonamide)-undecanoic acid and
N-12-(
p-iodophenylsulfonamide)-dodecanoic acid, were radioiodinated by exchange with cupric sulfate catalysis. Tissue distribution studies of the radioiodinated acids were performed in mice. Negligible myocardial uptake and rapid renal excretion of the radio-activity was observed with both compounds. The results suggest that the sulfonamide group perturbs the fatty acids to the extent that myocardial uptake is prevented. |
| doi_str_mv | 10.1016/0020-708X(82)90046-1 |
| format | article |
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N-11-(
p-iodophenylsulfonamide)-undecanoic acid and
N-12-(
p-iodophenylsulfonamide)-dodecanoic acid, were radioiodinated by exchange with cupric sulfate catalysis. Tissue distribution studies of the radioiodinated acids were performed in mice. Negligible myocardial uptake and rapid renal excretion of the radio-activity was observed with both compounds. The results suggest that the sulfonamide group perturbs the fatty acids to the extent that myocardial uptake is prevented.</description><identifier>ISSN: 0020-708X</identifier><identifier>DOI: 10.1016/0020-708X(82)90046-1</identifier><identifier>PMID: 7107040</identifier><language>eng</language><publisher>United States: Elsevier B.V</publisher><subject>Animals ; Heart - diagnostic imaging ; Iodine Radioisotopes ; Iodobenzenes - chemical synthesis ; Iodobenzenes - metabolism ; Isotope Labeling ; Male ; Mice ; Radionuclide Imaging ; Tissue Distribution</subject><ispartof>The International journal of applied radiation and isotopes, 1982-06, Vol.33 (6), p.451-453</ispartof><rights>1982</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-d499220b21f5cb7370df860f953f5512e57ada1664f9cef2769eb51ffd1db4523</citedby><cites>FETCH-LOGICAL-c357t-d499220b21f5cb7370df860f953f5512e57ada1664f9cef2769eb51ffd1db4523</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0020708X82900461$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3632,27924,27925,46012</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7107040$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fritzberg, Alan R.</creatorcontrib><creatorcontrib>Eshima, Dennis</creatorcontrib><title>Iodophenylsulfonamide fatty acid analogs as potential myocardial imaging agents</title><title>The International journal of applied radiation and isotopes</title><addtitle>Int J Appl Radiat Isot</addtitle><description>Two phenylsulfonamide fatty acid analogs were synthesized and radioiodinated as potential myocardial imaging agents that might be taken up in the cells and metabolically trapped. The acids,
N-11-(
p-iodophenylsulfonamide)-undecanoic acid and
N-12-(
p-iodophenylsulfonamide)-dodecanoic acid, were radioiodinated by exchange with cupric sulfate catalysis. Tissue distribution studies of the radioiodinated acids were performed in mice. Negligible myocardial uptake and rapid renal excretion of the radio-activity was observed with both compounds. The results suggest that the sulfonamide group perturbs the fatty acids to the extent that myocardial uptake is prevented.</description><subject>Animals</subject><subject>Heart - diagnostic imaging</subject><subject>Iodine Radioisotopes</subject><subject>Iodobenzenes - chemical synthesis</subject><subject>Iodobenzenes - metabolism</subject><subject>Isotope Labeling</subject><subject>Male</subject><subject>Mice</subject><subject>Radionuclide Imaging</subject><subject>Tissue Distribution</subject><issn>0020-708X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><recordid>eNp9kMtKxDAUhrNQxnH0DRS6El1Uk7Rp2o0gg5eBgdkouAtpclIjbVOTVujb2zqDS1fn8p_rh9AFwbcEk-wOY4pjjvP365zeFBinWUyO0PIvfYJOQ_icQlpk-QItOMEcp3iJdhunXfcB7ViHoTaulY3VEBnZ92MkldWRbGXtqhDJEHWuh7a3so6a0Snp9ezaRla2rSJZTVo4Q8dG1gHOD3aF3p4eX9cv8Xb3vFk_bGOVMN7HOi0KSnFJiWGq5AnH2uQZNgVLDGOEAuNSS5JlqSkUGMqzAkpGjNFElymjyQpd7ed23n0NEHrR2KCgrmULbgiCp6TIk4RPhem-UHkXggcjOj-d7EdBsJjZiRmSmCGJnIpfdoJMbZeH-UPZgP5rOoCb9Pu9DtOT3xa8CMpCq0BbD6oX2tn_F_wAxTaBGQ</recordid><startdate>198206</startdate><enddate>198206</enddate><creator>Fritzberg, Alan R.</creator><creator>Eshima, Dennis</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198206</creationdate><title>Iodophenylsulfonamide fatty acid analogs as potential myocardial imaging agents</title><author>Fritzberg, Alan R. ; Eshima, Dennis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-d499220b21f5cb7370df860f953f5512e57ada1664f9cef2769eb51ffd1db4523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Animals</topic><topic>Heart - diagnostic imaging</topic><topic>Iodine Radioisotopes</topic><topic>Iodobenzenes - chemical synthesis</topic><topic>Iodobenzenes - metabolism</topic><topic>Isotope Labeling</topic><topic>Male</topic><topic>Mice</topic><topic>Radionuclide Imaging</topic><topic>Tissue Distribution</topic><toplevel>online_resources</toplevel><creatorcontrib>Fritzberg, Alan R.</creatorcontrib><creatorcontrib>Eshima, Dennis</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The International journal of applied radiation and isotopes</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fritzberg, Alan R.</au><au>Eshima, Dennis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Iodophenylsulfonamide fatty acid analogs as potential myocardial imaging agents</atitle><jtitle>The International journal of applied radiation and isotopes</jtitle><addtitle>Int J Appl Radiat Isot</addtitle><date>1982-06</date><risdate>1982</risdate><volume>33</volume><issue>6</issue><spage>451</spage><epage>453</epage><pages>451-453</pages><issn>0020-708X</issn><abstract>Two phenylsulfonamide fatty acid analogs were synthesized and radioiodinated as potential myocardial imaging agents that might be taken up in the cells and metabolically trapped. The acids,
N-11-(
p-iodophenylsulfonamide)-undecanoic acid and
N-12-(
p-iodophenylsulfonamide)-dodecanoic acid, were radioiodinated by exchange with cupric sulfate catalysis. Tissue distribution studies of the radioiodinated acids were performed in mice. Negligible myocardial uptake and rapid renal excretion of the radio-activity was observed with both compounds. The results suggest that the sulfonamide group perturbs the fatty acids to the extent that myocardial uptake is prevented.</abstract><cop>United States</cop><pub>Elsevier B.V</pub><pmid>7107040</pmid><doi>10.1016/0020-708X(82)90046-1</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0020-708X |
| ispartof | The International journal of applied radiation and isotopes, 1982-06, Vol.33 (6), p.451-453 |
| issn | 0020-708X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74198337 |
| source | Backfile Package - Physics General (Legacy) [YPA] |
| subjects | Animals Heart - diagnostic imaging Iodine Radioisotopes Iodobenzenes - chemical synthesis Iodobenzenes - metabolism Isotope Labeling Male Mice Radionuclide Imaging Tissue Distribution |
| title | Iodophenylsulfonamide fatty acid analogs as potential myocardial imaging agents |
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