Germinal centers and the B-cell system. VII. Complement receptors, antigen receptors, immunoglobulin and alkaline phosphatase in germinal centers of the rabbit appendix and popliteal lymph nodes

Germinal centers of the rabbit appendix were studied for the presence of complement receptors, immunoglobulin and alkaline phosphatase. In popliteal lymph nodes, de novo-developing germinal centers were studied with respect to these markers up to 21 days after sheep red blood cell (SRBC)-stimulation...

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Bibliographic Details
Published in:Cell and tissue research 1982, Vol.224 (3), p.505-516
Main Authors: Opstelten, D, Stikker, R, Deenen, G J, Nieuwenhuis, P
Format: Article
Language:English
Subjects:
Alkaline Phosphatase - metabolism
Animals
Appendix - cytology
Appendix - enzymology
Appendix - immunology
B-Lymphocytes - cytology
B-Lymphocytes - immunology
Cell Differentiation
Lymph Nodes - cytology
Lymph Nodes - enzymology
Lymph Nodes - immunology
Lymphocyte Activation
Rabbits
Receptors, Antigen, B-Cell - analysis
Receptors, Complement - analysis
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Summary:Germinal centers of the rabbit appendix were studied for the presence of complement receptors, immunoglobulin and alkaline phosphatase. In popliteal lymph nodes, de novo-developing germinal centers were studied with respect to these markers up to 21 days after sheep red blood cell (SRBC)-stimulation. In addition, the possible presence of antigen (SRBC) receptor-bearing cells in these germinal centers was investigated. Microenvironmental differences were shown between the densely populated area and the thinly populated area of germinal centers. However, no indication was obtained for a postulated maturation event of the lymphocytes within germinal centers, or for functional differences that may exist between germinal centers in the appendix and popliteal lymph nodes.
ISSN:0302-766X
1432-0878
DOI:10.1007/BF00213748