Effect of calcium and calmodulin on RNA synthesis in isolated nuclei from rat liver cells

The authors investigated the effects of calcium, calmodulin and the calmodulin inhibitor, chlorpromazine, on RNA synthesis in isolated nuclei from rat liver cells. The results show that calcium inhibits RNA synthesis and that this effect is not dependent on calmodulin.

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Bibliographic Details
Published in:FEBS letters 1982-06, Vol.143 (1), p.157-160
Main Authors: Pardo, J.P., Fernández, F.
Format: Article
Language:English
Subjects:
Animals
Calcium - pharmacology
Calcium-Binding Proteins - pharmacology
Calmodulin - pharmacology
Cell Nucleus - drug effects
Cell Nucleus - metabolism
Egtazic Acid - pharmacology
Kinetics
Liver - metabolism
Rats
RNA - genetics
Transcription, Genetic - drug effects
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Description
Summary:The authors investigated the effects of calcium, calmodulin and the calmodulin inhibitor, chlorpromazine, on RNA synthesis in isolated nuclei from rat liver cells. The results show that calcium inhibits RNA synthesis and that this effect is not dependent on calmodulin.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(82)80295-0