Hepatitis B Virus and HLA Antigen Display in the Liver During Chronic Hepatitis B Virus Infection

An analysis of the expression of the histocompatibility antigens in the livers of patients with chronic hepatitis B virus infection and normal subjects has demonstrated an increased expression of HLA‐A,B,C antigens on the hepatocytes of patients with a low level of viral replication (HBe antibody po...

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Bibliographic Details
Published in:Hepatology (Baltimore, Md.) Md.), 1982-09, Vol.2 (5), p.557S-561S
Main Authors: Montan̄to, Luis, Miescher, Guido C., Goodall, Alison H., Wiedmann, Karl H., Janossy, George, Thomas, Howard C.
Format: Article
Language:English
Subjects:
Biopsy
Chronic Disease
Hepatitis B - immunology
Hepatitis B e Antigens - analysis
Hepatitis B Surface Antigens - analysis
HLA Antigens - analysis
Humans
Liver - analysis
Liver - pathology
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Summary:An analysis of the expression of the histocompatibility antigens in the livers of patients with chronic hepatitis B virus infection and normal subjects has demonstrated an increased expression of HLA‐A,B,C antigens on the hepatocytes of patients with a low level of viral replication (HBe antibody positive) as compared with patients who exhibit a high level of viral replication (HBe antigen positive) and controls. This increase in the expression of histocompatibility antigens on the hepatocytes was associated with a decrease in the membrane expression of viral antigens by the same cells. These differences in the density of HLA and viral antigen display may influence the efficiency of T‐cell cytolysis of hepatitis B virus‐infected hepatocytes.
ISSN:0270-9139
1527-3350
DOI:10.1002/hep.1840020508