Differences in Sialic Acid Content of Human Interferons

* Department of Biological Sciences Department of Chemistry and Molecular Sciences University of Warwick, Coventry CV4 7AL, U.K. Human leucocyte, lymphoblastoid and fibroblast interferons were separately treated with sialidase and the effect of this on their isoelectric focusing was examined using a...

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Bibliographic Details
Published in:Journal of general virology 1978-10, Vol.41 (1), p.175-178
Main Authors: Morser, J, Kabayo, J. P, Hutchinson, D. W
Format: Article
Language:English
Subjects:
Fibroblasts
Humans
Interferons - analysis
Isoelectric Point
Leukocytes
Lymphocytes
Neuraminidase
Sialic Acids - analysis
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Summary:* Department of Biological Sciences Department of Chemistry and Molecular Sciences University of Warwick, Coventry CV4 7AL, U.K. Human leucocyte, lymphoblastoid and fibroblast interferons were separately treated with sialidase and the effect of this on their isoelectric focusing was examined using a system in which full dissociation of complexes occurred. Both leucocyte and lymphoblastoid interferons showed a single form with an isoelectric point which was unaltered by treatment with sialidase. In contrast, fibroblast interferon showed three forms which were reduced to one by treatment with the enzyme. Received 25 January 1978; accepted 15 May 1978.
ISSN:0022-1317
1465-2099
DOI:10.1099/0022-1317-41-1-175