Survival of Pacinian corpuscles after denervation in adult rats

The ultrastructure of Pacinian corpuscles located on the crural interosseous membrane was studied in adult rats 6h to 10 months after transection of the right sciatic nerve. Axon terminals degenerated one day after transection and were engulfed and resorbed by cells of the inner core within one week...

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Bibliographic Details
Published in:Cell and tissue research 1982-01, Vol.224 (3), p.673-683
Main Author: Zelen, Ji?ina
Format: Article
Language:English
Subjects:
Animals
Atrophy
Axons - ultrastructure
Cell Division
Cell Membrane - ultrastructure
Denervation
Female
Mechanoreceptors - ultrastructure
Microscopy, Electron
Mitochondria - ultrastructure
Nerve Degeneration
Pacinian Corpuscles - physiology
Pacinian Corpuscles - ultrastructure
Rats
Rats, Inbred Strains
Schwann Cells - ultrastructure
Sciatic Nerve
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Summary:The ultrastructure of Pacinian corpuscles located on the crural interosseous membrane was studied in adult rats 6h to 10 months after transection of the right sciatic nerve. Axon terminals degenerated one day after transection and were engulfed and resorbed by cells of the inner core within one week. The axial space left after removal of the axonal debris was closed by the lamellae of the inner core. The main structural features of the inner core and capsule remained preserved after denervation throughout the period of study. The denervated inner cores, however, became atrophic 10 months after neurotomy, their mean diameter being reduced by 17.5% compared with that of contralateral control corpuscles. The number of capsular lamellae was unaltered, and perineurial pathways of the peripheral nerve stump remained preserved. Schwann cells proliferated and formed Büngner bands during the first month after denervation, but retracted their processes and became atrophic at later stages after neurotomy. Survival of Pacinian corpuscles after long-term denervation in adult rats is in contrast to their rapid degeneration within several days after nerve section in neonates.
ISSN:0302-766X
1432-0878
DOI:10.1007/BF00213762