Belladonna Alkaloids and Phenobarbital Combination Pharmaceuticals Analysis I: High-Performance Liquid Chromatographic Determinations of Hyoscyamine-Atropine and Scopolamine

High-performance liquid chromatographic separations are described for the analysis of hyoscyamine-atropine and scopolamine in combination pharmaceutical dosage forms containing phenobarbital. A mobile phase containing 0.034 M tetramethylammonium phosphate in water–methanol (21:10, pH 2.0) separated...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1982-08, Vol.71 (8), p.951-953
Main Authors: Pennington, Linda J., Schmidt, Walter F.
Format: Article
Language:English
Subjects:
Alkaloids-belladonna
Alkaloids—belladonna, combination Pharmaceuticals, high‐performance liquid chromatographic determination of hyoscyamine‐atropine and scopolamine
Atropine - analysis
Capsules - analysis
Chromatography, High Pressure Liquid - methods
Combination drugs-belladonna alkaloids
Combination drugs—belladonna alkaloids, high-performance liquid chromatographic determination of hyoscyamine-atropine and scopolamine
combination Pharmaceuticals
determination of hyoscyamine-atropine and scopolamine
Drug Combinations
Drug Stability
high-performance liquid chromatographic determination of hyoscyamine-atropine and scopolamine
High-performance liquid chromatography-belladonna alkaloids and phenobarbital combination Pharmaceuticals
High-performance liquid chromatography—belladonna alkaloids and phenobarbital combination pharmaceuticals, determination of hyoscyamine-atropine and scopolamine
Phenobarbital - analysis
Scopolamine - analysis
Solutions - analysis
Tablets - analysis
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Description
Summary:High-performance liquid chromatographic separations are described for the analysis of hyoscyamine-atropine and scopolamine in combination pharmaceutical dosage forms containing phenobarbital. A mobile phase containing 0.034 M tetramethylammonium phosphate in water–methanol (21:10, pH 2.0) separated hyoscyamine or atropine from scopolamine on an octadecylsilane column in
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600710830