Nutritional & Pharmacologic Management of Hyperlipoproteinemia

The results of the nutritional intervention on one of the twenty MRFIT centers is presented. The reduction in cholesterol was 5.78% after four years. Those results were compared with the changes found in serum cholesterol with a similar diet and the administration of either clofibrate or gemfibrozil...

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Bibliographic Details
Published in:Angiology 1982-09, Vol.33 (9), p.577-580
Main Author: Pickering, J. Edward
Format: Article
Language:English
Subjects:
Cholesterol - blood
Cholesterol, Dietary - administration & dosage
Clofibrate - therapeutic use
Dietary Fats - administration & dosage
Gemfibrozil
Humans
Hyperlipoproteinemias - blood
Hyperlipoproteinemias - drug therapy
Hyperlipoproteinemias - therapy
Hypolipidemic Agents - therapeutic use
Lipoproteins, VLDL - blood
Pentanoic Acids - therapeutic use
Valerates - therapeutic use
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Summary:The results of the nutritional intervention on one of the twenty MRFIT centers is presented. The reduction in cholesterol was 5.78% after four years. Those results were compared with the changes found in serum cholesterol with a similar diet and the administration of either clofibrate or gemfibrozil. The reduction with clofibrate remained at 5%. However with gemfibrozil the reduction in cholesterol was 16%. The HDL level rose in half of these patients treated with either clofibrate or gemfibrozil. The results without concurrent dietary restriction usually show a greater reduction in VLDL and a greater rise in HDL than we found when nutritional and pharmacologic intervention were combined.
ISSN:0003-3197
1940-1574
DOI:10.1177/000331978203300903