The use of tinidazole in the surgery of oral tumours

The oropharynx has a rich anaerobic flora, and foul odour often occurs in squamous cancers. Wound infections are common after radical surgery for cancer. In a double-blind trial tinidazole or placebo was given to patients undergoing major resections of intra-oral squamous carcinomas. Tinidazole was...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 1982-01, Vol.10 (suppl-A), p.173-175
Main Authors: McGregor, Ian A., Watson, James D., Sweeney, Grace, Sleigh, J. Douglas
Format: Article
Language:English
Subjects:
Aerobiosis
Anaerobiosis
Double-Blind Method
Humans
Mouth Neoplasms - surgery
Nitroimidazoles - therapeutic use
Odorants
Premedication
Tinidazole - therapeutic use
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Summary:The oropharynx has a rich anaerobic flora, and foul odour often occurs in squamous cancers. Wound infections are common after radical surgery for cancer. In a double-blind trial tinidazole or placebo was given to patients undergoing major resections of intra-oral squamous carcinomas. Tinidazole was given in a dose of 8 g over seven days. Placebo tablets were given to the other group. Tinidazole proved to be effective in preventing post-operative wound infections and clinically eliminating the smell associated with the discharge. In the placebo group, a majority of the patients became infected and had a foul smell. Aerobic bacteria and a variety of anaerobic Gram-negative bacilli were present in these patients. After eight patients were treated, the results were so clear-cut that the placebo part of the trial was stopped.
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/10.suppl_A.173