Fluorescent histochemical localisation of quinacrine-positive neurones in the guinea-pig and rabbit atrium

Quinacrine-fluorescent nerve fibres and nerve cell bodies are described in the right and left atria of the guinea-pig and rabbit. The nerve cells (20 to 35 μm in diameter) are found predominantly in the right atrium in both species. The nerve fibres are varicose and innervate both the muscle and man...

Full description

Saved in:
Bibliographic Details
Published in:Cardiovascular research 1982-07, Vol.16 (7), p.384-390
Main Authors: CROWE, RAHIMA, BURNSTOCK, GEOFFREY
Format: Article
Language:English
Subjects:
Acetylcholinesterase - analysis
Animals
Biological and medical sciences
Catecholamines - analysis
Fluorescence
Fundamental and applied biological sciences. Psychology
Guinea Pigs
Heart
Heart Atria - analysis
Heart Atria - innervation
Male
Nerve Fibers - analysis
Neurons - analysis
Quinacrine - analysis
Rabbits
Vertebrates: cardiovascular system
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Quinacrine-fluorescent nerve fibres and nerve cell bodies are described in the right and left atria of the guinea-pig and rabbit. The nerve cells (20 to 35 μm in diameter) are found predominantly in the right atrium in both species. The nerve fibres are varicose and innervate both the muscle and many blood vessels. The quinacrine fluorescent neural structures are unaffected by chemical sympathectomy with 6-hydroxydopamine. The distribution of quinacrine-positive nerve fibres and cell bodies are compared to the distribution of adrenergic and acetylcholinesterase-positive nerves in the atrium of both species. Quinacrine fluorescence appears to be selective for non-adrenergic, non-cholinergic nerves and the possibility that it is binding to high contents of ATP is discussed.
ISSN:0008-6363
1755-3245
DOI:10.1093/cvr/16.7.384