Erythroid Regulatory Factors: Correlation of Detectable Titers In Vivo and In Vitro

Titers of erythroid regulatory factors (ERF), as measured in vivo with a standard erythrocythemic mouse technique, showed a highly significant correlation with those obtained in vitro with a fetal mouse liver cell (FMLC) assay. The results from the assay in vitro were somewhat higher than would be p...

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Bibliographic Details
Published in:Blood 1978-12, Vol.52 (6), p.1238-1242
Main Authors: Dunn, C.D.R., Lange, R.D.
Format: Article
Language:English
Subjects:
Animals
Erythropoiesis
Erythropoietin - urine
Female
Fetus - cytology
Humans
Liver - cytology
Mice
Mice, Inbred C3H
Polycythemia - blood
Pregnancy
Space life sciences
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Summary:Titers of erythroid regulatory factors (ERF), as measured in vivo with a standard erythrocythemic mouse technique, showed a highly significant correlation with those obtained in vitro with a fetal mouse liver cell (FMLC) assay. The results from the assay in vitro were somewhat higher than would be predicted from the assay in vivo. Nevertheless, the FMLC technique has been found to be a valid and useful technique particularly in the study of serum ERF titers.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V52.6.1238.1238