Lysosomal changes in fatty liver induced in rats by high protein pyridoxine-deficient diet

The effect of high-protein pyridoxine-deficient diet on the localization of lysosomes and acid phosphatase activity in the rat liver was studied using light and electron microscopy. Numerous lysosomes con-taining lipid droplets appeared to arise directly from GERI (Golgi apparatus, endoplasmic retic...

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Bibliographic Details
Published in:Journal of Nutritional Science and Vitaminology 1982, Vol.28(3), pp.209-216
Main Authors: Kishino, Y, Abe, M
Format: Article
Language:English
Subjects:
acid phosphatase
Acid Phosphatase - metabolism
Animals
Dietary Proteins - adverse effects
fatty liver
Fatty Liver - etiology
Fatty Liver - pathology
Lipase - metabolism
Lipid Metabolism
lysosomes
Lysosomes - ultrastructure
Male
pyridoxine
pyridoxine deficiency
Rats
Rats, Inbred Strains
Vitamin B 6 Deficiency - complications
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Summary:The effect of high-protein pyridoxine-deficient diet on the localization of lysosomes and acid phosphatase activity in the rat liver was studied using light and electron microscopy. Numerous lysosomes con-taining lipid droplets appeared to arise directly from GERI (Golgi apparatus, endoplasmic reticulum and lysosomes) near bile canaliculi and thereafter large crystal clefts were frequently found in these lysosomes. The increased appearance of lysosomes in hepatocytes was compatible with increased lipid droplets and represented an indication of breakdown of stored lipids. Acid phosphatase activity was localized almost exclusively in lysosomes with or without lipid droplets. We postulated that one of the causes of accumulation of lipid in hepatocytes, including that of tri-glyceride and cholesteryl ester, might be associated with a relative deficiency of intralysosomal digestion in these conditions.
ISSN:0301-4800
1881-7742
DOI:10.3177/jnsv.28.209