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Lysosomal changes in fatty liver induced in rats by high protein pyridoxine-deficient diet

The effect of high-protein pyridoxine-deficient diet on the localization of lysosomes and acid phosphatase activity in the rat liver was studied using light and electron microscopy. Numerous lysosomes con-taining lipid droplets appeared to arise directly from GERI (Golgi apparatus, endoplasmic retic...

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Published in:	Journal of Nutritional Science and Vitaminology 1982, Vol.28(3), pp.209-216
Main Authors:	Kishino, Y, Abe, M
Format:	Article
Language:	English
Subjects:	acid phosphatase Acid Phosphatase - metabolism Animals Dietary Proteins - adverse effects fatty liver Fatty Liver - etiology Fatty Liver - pathology Lipase - metabolism Lipid Metabolism lysosomes Lysosomes - ultrastructure Male pyridoxine pyridoxine deficiency Rats Rats, Inbred Strains Vitamin B 6 Deficiency - complications
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container_title	Journal of Nutritional Science and Vitaminology
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creator	Kishino, Y Abe, M
description	The effect of high-protein pyridoxine-deficient diet on the localization of lysosomes and acid phosphatase activity in the rat liver was studied using light and electron microscopy. Numerous lysosomes con-taining lipid droplets appeared to arise directly from GERI (Golgi apparatus, endoplasmic reticulum and lysosomes) near bile canaliculi and thereafter large crystal clefts were frequently found in these lysosomes. The increased appearance of lysosomes in hepatocytes was compatible with increased lipid droplets and represented an indication of breakdown of stored lipids. Acid phosphatase activity was localized almost exclusively in lysosomes with or without lipid droplets. We postulated that one of the causes of accumulation of lipid in hepatocytes, including that of tri-glyceride and cholesteryl ester, might be associated with a relative deficiency of intralysosomal digestion in these conditions.
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Numerous lysosomes con-taining lipid droplets appeared to arise directly from GERI (Golgi apparatus, endoplasmic reticulum and lysosomes) near bile canaliculi and thereafter large crystal clefts were frequently found in these lysosomes. The increased appearance of lysosomes in hepatocytes was compatible with increased lipid droplets and represented an indication of breakdown of stored lipids. Acid phosphatase activity was localized almost exclusively in lysosomes with or without lipid droplets. 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source	J-STAGE (Japan Science & Technology Information Aggregator, Electronic) - Open Access English articles
subjects	acid phosphatase Acid Phosphatase - metabolism Animals Dietary Proteins - adverse effects fatty liver Fatty Liver - etiology Fatty Liver - pathology Lipase - metabolism Lipid Metabolism lysosomes Lysosomes - ultrastructure Male pyridoxine pyridoxine deficiency Rats Rats, Inbred Strains Vitamin B 6 Deficiency - complications
title	Lysosomal changes in fatty liver induced in rats by high protein pyridoxine-deficient diet
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