Digoxin, whole body potassium and the electrocardiogram

Previous studies have shown a significant linear relationship between the PTQ-index (a combination function of the PR-interval, corrected QT-time and T-wave depression in the ECG) and serum digoxin level in chronically treated patients. The relationship was confirmed in the present study and it was...

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Bibliographic Details
Published in:European journal of clinical pharmacology 1978-11, Vol.14 (2), p.101-104
Main Authors: Joubert, P H, Müller, F O, van Rijssen, F W, Malan, J, Iturralde, M P, van Reenen, O R
Format: Article
Language:English
Subjects:
Adult
Digoxin - blood
Digoxin - pharmacology
Electrocardiography
Furosemide - pharmacology
Humans
Male
Potassium - blood
Potassium - physiology
Potassium Chloride - pharmacology
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Summary:Previous studies have shown a significant linear relationship between the PTQ-index (a combination function of the PR-interval, corrected QT-time and T-wave depression in the ECG) and serum digoxin level in chronically treated patients. The relationship was confirmed in the present study and it was shown that it could be changed by concomitant administration of potassium chloride or furosemide, and that there was marked interindividual variation in response. An inverse linear relationship between PTQ-index and whole body potassium was found during chronic administration of a constant daily dose of digoxin, but no such relationship was found for serum potassium.
ISSN:0031-6970
1432-1041
DOI:10.1007/BF00607439