Eurotium (Aspergillus) repens metabolites and their biological activity

Eurotium repens mycelium cultivated under static conditions was used to isolate and identify metabolities--echinulin, physcion, erythroglaucin, flavoglaucin and asperentin; the filtrate of the culture yielded asperentin 8-methylether. The broadest biological activity spectrum was displayed by aspere...

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Bibliographic Details
Published in:Folia microbiologica 1978-01, Vol.23 (6), p.438-443
Main Authors: Podojil, M, Sedmera, P, Vokoun, J, Betina, V, Barathova, H, Durackova, Z, Horakova, K, Nemec, P
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - biosynthesis
Anti-Bacterial Agents - pharmacology
Antifungal Agents - biosynthesis
Antifungal Agents - pharmacology
Artemia - drug effects
Aspergillus
Aspergillus - metabolism
Bacillus subtilis - drug effects
fungi
HeLa Cells - drug effects
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
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Summary:Eurotium repens mycelium cultivated under static conditions was used to isolate and identify metabolities--echinulin, physcion, erythroglaucin, flavoglaucin and asperentin; the filtrate of the culture yielded asperentin 8-methylether. The broadest biological activity spectrum was displayed by asperentin which had antibacterial and antifungal effects and, at a concentration of 86 microgram/ml, caused 50% mor7 tality in Artemia saline larvae. The highest cytotoxicity towards HeLa cells was found in physcion which caused 50% growth inhibition at a concentration of 0.1 microgram/ml.
ISSN:0015-5632
1874-9356
DOI:10.1007/BF02885572