Specific effect of zinc ions on DNA polymerase activity of avian myeloblastosis virus

The effect of selected cations on DNA synthesis by DNA-polymerase of avian myeloblastosis virus (AMV) was studied. Zinc ions at low concentration (0.2mM) in the assay system enhanced the activity about 2 x fold and at higher concentration (2.0 mM) inhibited the activity completely. In contrast, addi...

Full description

Saved in:
Bibliographic Details
Published in:Molecular and cellular biochemistry 1978-11, Vol.21 (2), p.67-69
Main Authors: Palan, P.R, Eidinoff, M.L
Format: Article
Language:English
Subjects:
animal diseases
animal health
Avian Leukosis Virus - enzymology
Avian Myeloblastosis Virus - enzymology
DNA - biosynthesis
DNA-Directed DNA Polymerase - metabolism
Enzyme Activation
Lithium - pharmacology
Nucleic Acid Synthesis Inhibitors
Potassium - pharmacology
Zinc - administration & dosage
Zinc - pharmacology
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The effect of selected cations on DNA synthesis by DNA-polymerase of avian myeloblastosis virus (AMV) was studied. Zinc ions at low concentration (0.2mM) in the assay system enhanced the activity about 2 x fold and at higher concentration (2.0 mM) inhibited the activity completely. In contrast, addition of lithium and potassium salts produced inhibitory effects in this ionic concentration range. Replacement of K+ ion had an inhibitory effect on the activity.
ISSN:0300-8177
1573-4919
DOI:10.1007/BF00240277