Specific effect of zinc ions on DNA polymerase activity of avian myeloblastosis virus

The effect of selected cations on DNA synthesis by DNA-polymerase of avian myeloblastosis virus (AMV) was studied. Zinc ions at low concentration (0.2mM) in the assay system enhanced the activity about 2 x fold and at higher concentration (2.0 mM) inhibited the activity completely. In contrast, addi...

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Published in:Molecular and cellular biochemistry 1978-11, Vol.21 (2), p.67-69
Main Authors: Palan, P.R, Eidinoff, M.L
Format: Article
Language:English
Subjects:
animal diseases
animal health
Avian Leukosis Virus - enzymology
Avian Myeloblastosis Virus - enzymology
DNA - biosynthesis
DNA-Directed DNA Polymerase - metabolism
Enzyme Activation
Lithium - pharmacology
Nucleic Acid Synthesis Inhibitors
Potassium - pharmacology
Zinc - administration & dosage
Zinc - pharmacology
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cited_by cdi_FETCH-LOGICAL-c305t-7ccf6df14fcd39c1fae2b051825e3e6a973317f8193ab876e4aa4f6c6209d0363
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container_title Molecular and cellular biochemistry
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creator Palan, P.R
Eidinoff, M.L
description The effect of selected cations on DNA synthesis by DNA-polymerase of avian myeloblastosis virus (AMV) was studied. Zinc ions at low concentration (0.2mM) in the assay system enhanced the activity about 2 x fold and at higher concentration (2.0 mM) inhibited the activity completely. In contrast, addition of lithium and potassium salts produced inhibitory effects in this ionic concentration range. Replacement of K+ ion had an inhibitory effect on the activity.
doi_str_mv 10.1007/BF00240277
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ispartof Molecular and cellular biochemistry, 1978-11, Vol.21 (2), p.67-69
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source Springer Online Journal Archives (Through 1996)
subjects animal diseases
animal health
Avian Leukosis Virus - enzymology
Avian Myeloblastosis Virus - enzymology
DNA - biosynthesis
DNA-Directed DNA Polymerase - metabolism
Enzyme Activation
Lithium - pharmacology
Nucleic Acid Synthesis Inhibitors
Potassium - pharmacology
Zinc - administration & dosage
Zinc - pharmacology
title Specific effect of zinc ions on DNA polymerase activity of avian myeloblastosis virus
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